DNA-based nanocomposites with secondary structure for precision treatment of tumor

作者全名："Cheng, Xiangshu; Zhou, Ping; Chen, Changmei; Liu, Fengyuan; Wang, Lulu; Yi, Rongchun; Yu, Chao; Deng, Tao"

作者地址："[Cheng, Xiangshu; Zhou, Ping; Chen, Changmei; Liu, Fengyuan; Wang, Lulu; Yi, Rongchun; Yu, Chao; Deng, Tao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Cheng, Xiangshu; Zhou, Ping; Chen, Changmei; Liu, Fengyuan; Wang, Lulu; Yi, Rongchun; Yu, Chao; Deng, Tao] Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 400016, Peoples R China; [Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China"

通信作者："Yu, C; Deng, T (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:001370366300001

JCR分区：Q1

影响因子：15.1

年份：2024

卷号：502

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：DNA; Carbon dots; Multi-level structures; Responsive release; Tumor treatment

摘要："Carbon dots (CDs) have been extensively studied in tumor therapy due to their excellent compatibility, remarkable stability, and luminescent properties. However, CDs-based therapeutic agents often face limitations such as rapid clearance, poor targeting, and weak responsiveness, which hinder their efficacy in achieving precise tumor treatment. To address these challenges, this study presents the construction of a dual-targeting, dual-responsive drug delivery platform with hierarchical structures: MV-DNA-CDs@DOX. Firstly, methacrylic acid-coated o-phenylenediamine carbon dots were synthesized using methacrylic acid and o-phenylenediamine. This was then conjugated with an i-motif-containing DNA sequence to create DNA-CDs with a ""yarn ball-like"" secondary structure. The nano-particles preserved the acid-responsive nature of the sequence and introduced an additional photo-responsive characteristic, enhancing the nanocarrier's ability to deliver drugs deeply into tumor tissues. Upon loading with DOX, the polymeric nanocarrier was subject to biomimetic treatment, endowing it with active tumor-targeting capabilities and improving the specific distribution of the drug within tumor sites. Therefore, the use of biocompatible and responsive DNA segments as crosslinkers to construct organic nanopolymer carriers in the preparation of anti-tumor nanomaterials holds promise in expanding the application of nanotechnology in the field of cancer treatment."

基金机构：Future Medical Youth Innovation Team Support Program of Chongqing Medical University [W0090]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0849]; Chongqing Special Project for Technological Innovation and Application Development [cstc2020jscx-msxmX0070]; Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing University

基金资助正文："This work was financially supported by Future Medical Youth Innovation Team Support Program of Chongqing Medical University (W0090) , Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0849) , Chongqing Special Project for Technological Innovation and Application Development (cstc2020jscx-msxmX0070) . We sincerely thank Research Center of Pharmaceutical Preparations and Nano-medicine and Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing University for the support of the work."