"Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study"

作者全名："Hu, Chunyan; Zhang, Yi; Zhang, Jie; Huo, Yanan; Wan, Qin; Li, Mian; Qi, Hongyan; Du, Rui; Zhu, Yuanyue; Qin, Yingfen; Hu, Ruying; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Qin, Guijun; Tang, Xulei; Chen, Gang; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Chen, Li; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Chen, Lulu; Zhao, Jiajun; Mu, Yiming; Wang, Weiqing; Xu, Yu; Bi, Yufang; Lu, Jieli; Ning, Guang"

作者地址："[Hu, Chunyan; Zhang, Yi; Zhang, Jie; Li, Mian; Qi, Hongyan; Du, Rui; Zhu, Yuanyue; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Wang, Weiqing; Xu, Yu; Bi, Yufang; Lu, Jieli; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China; [Hu, Chunyan; Zhang, Yi; Zhang, Jie; Li, Mian; Qi, Hongyan; Du, Rui; Zhu, Yuanyue; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Wang, Weiqing; Xu, Yu; Bi, Yufang; Lu, Jieli; Ning, Guang] Shanghai Jiao Tong Univ, Key Lab Endocrine & Metab Dis Natl Hlth Commiss P, Shanghai Natl Clin Res Ctr Metab Dis,Sch Med, Shanghai Natl Ctr Translat Med,Ruijin Hosp, Shanghai, Peoples R China; [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China; [Wan, Qin] Luzhou Med Coll, Affiliated Hosp, Luzhou, Peoples R China; [Qin, Yingfen; Luo, Zuojie] Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China; [Hu, Ruying; Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China; [Shi, Lixin] Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China; [Su, Qing] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China; [Qin, Guijun] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Tang, Xulei] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dalian, Peoples R China; [Wang, Guixia] Jilin Univ, Hosp 1, Changchun, Peoples R China; [Shen, Feixia] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; [Chen, Li] Shandong Univ, Qilu Hosp, Jinan, Peoples R China; [Li, Qiang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China; [Wang, Youmin] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China; [Yang, Tao] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China; [Deng, Huacong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Lulu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Zhao, Jiajun] Shandong Univ, Shandong Prov Hosp, Jinan, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China"

通信作者："Lu, JL (corresponding author), Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp, Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China."

来源：JOURNAL OF DIABETES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000603145900001

JCR分区：Q2

影响因子：4.5

年份：2021

卷号：13

期号：6

开始页：458

结束页：468

文献类型：Article

关键词：age at menarche; cardiovascular health metrics; diabetes; lifestyle

摘要："Background Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear. Methods We included 121 431 women from the nationwide, population-based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes. Results The multivariable-adjusted odds ratios of diabetes across categories of age at menarche (<14, 14-17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction = .0001). Conclusions Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results."

基金机构："Shanghai Medical and Health Development Foundation [DMRFP_I_01]; Shanghai Outstanding Academic Leaders Plan [18XD1402500, 20XD1422800]; National Major Scientific and Technological Special Project for ""Significant New Drugs Development"" [2017ZX09304007]; Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2016YFC1304904, 2016YFC1305202, 2016YFC1305600, 2016YFC0901200, 2017YFC1310700, 2018YFC1311800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81561128019, 81670795, 81700764, 81970691, 81970728]"

基金资助正文："Shanghai Medical and Health Development Foundation, Grant/Award Number: DMRFP_I_01; Shanghai Outstanding Academic Leaders Plan, Grant/Award Numbers: 18XD1402500, 20XD1422800; the National Major Scientific and Technological Special Project for ""Significant New Drugs Development"", Grant/Award Number: 2017ZX09304007; the Ministry of Science and Technology of the People's Republic of China, Grant/Award Numbers: 2016YFC1304904, 2016YFC1305202, 2016YFC1305600, 2016YFC0901200, 2017YFC1310700, 2018YFC1311800; the National Natural Science Foundation of China, Grant/Award Numbers: 81561128019, 81670795, 81700764, 81970691, 81970728"