Improving quality of life in pancreatic cancer patients following high-intensity focused ultrasound (HIFU) in two European centers

作者全名："Marinova, Milka; Feradova, Hyuliya; Gonzalez-Carmona, Maria A.; Conrad, Rupert; Tonguc, Tolga; Thudium, Marcus; Becher, Marc U.; Kun, Zhou; Gorchev, Grigor; Tomov, Slavcho; Strassburg, Christian P.; Attenberger, Ulrike; Schild, Hans H.; Dimitrov, Dobromir; Strunk, Holger M."

作者地址："[Marinova, Milka; Tonguc, Tolga; Attenberger, Ulrike; Schild, Hans H.; Strunk, Holger M.] Univ Hosp Bonn, Clin Diagnost & Intervent Radiol, Venusberg Campus 1, D-53127 Bonn, Germany; [Feradova, Hyuliya; Gorchev, Grigor; Tomov, Slavcho; Dimitrov, Dobromir] Med Univ Pleven, Univ St Marina Hosp, HIFU Ctr, Pleven, Bulgaria; [Gonzalez-Carmona, Maria A.; Strassburg, Christian P.] Univ Hosp Bonn, Clin Internal Med 1, Bonn, Germany; [Conrad, Rupert] Univ Hosp Bonn, Clin Psychosomat Med & Psychotherapy, Bonn, Germany; [Thudium, Marcus] Univ Hosp Bonn, Dept Anaesthesiol, Bonn, Germany; [Becher, Marc U.] Univ Hosp Bonn, Clin Internal Med 2, Bonn, Germany; [Kun, Zhou] Chongqing Med Univ, Clin Ctr Tumor Therapy, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Strunk, HM (corresponding author), Univ Hosp Bonn, Clin Diagnost & Intervent Radiol, Venusberg Campus 1, D-53127 Bonn, Germany."

来源：EUROPEAN RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000610489900001

JCR分区：Q1

影响因子：5.9

年份：2021

卷号：31

期号：8

开始页：5818

结束页：5829

文献类型：Article

关键词：Pancreatic neoplasms; High-intensity focused ultrasound ablation; Palliative care; Pain management; Quality of life

摘要："Objectives Pancreatic cancer patients often have a high symptom burden, significantly impairing patients' quality of life (QOL). Nevertheless, there are hardly any reports on the impact of high-intensity focused ultrasound (HIFU) on the QOL of treated patients. For the first time, this study evaluated the effect of HIFU on QOL and compared these results in two European centers. Methods Eighty patients with advanced pancreatic cancer underwent HIFU (50 in Germany, 30 in Bulgaria). Clinical assessment included evaluation of QOL and symptoms using the EORTC QLQ-C30 questionnaire at baseline and 1, 3, and 6 months after HIFU. Pain intensity was additionally evaluated with the numerical rating score (NRS). Results Compared to baseline, global health significantly improved 3 and 6 months after HIFU treatment (p = 0.02). Functional subscales including physical, emotional, and social functioning were considerably improved at 6 months (p = 0.02, p = 0.01, and p = 0.01, respectively) as were leading symptom pain (p = 0.04 at 6 months), fatigue (p = 0.03 at 3 and p = 0.01 at 6 months), and appetite loss (p = 0.01 at 6 months). Moreover, pain intensity measured by NRS revealed effective and strong pain relief at all time points (p < 0.001). Reported effects were independent of tumor stage, metastatic status, and country of treatment. Conclusions This study showed that HIFU represents an effective treatment option of advanced pancreatic cancer improving QOL by increasing global health and mitigation of physical complaints with a low rate of side effects, independent of the examiner. Therefore, HIFU is a worthwhile additional treatment besides systemic palliative chemotherapy or best supportive care in management of this aggressive disease."

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