"The mental health of Chinese women with polycystic ovary syndrome is related to sleep disorders, not disease status"

作者全名："Yang, Yin; Deng, Hui; Li, Tian; Xia, Min; Liu, Chang; Bu, Xiao-Qing; Li, Hang; Fu, Li-Juan; Zhong, Zhao-Hui"

作者地址："[Yang, Yin; Bu, Xiao-Qing; Zhong, Zhao-Hui] Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth & Management, Dept Epidemiol,Innovat Ctr Social Risk Governance, Chongqing, Peoples R China; [Liu, Chang] Chongqing Med Univ, Sch Publ Hlth, Dept Reprod Biol, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Deng, Hui; Xia, Min; Li, Hang] Chongqing Hosp Tradit Chinese Med, Chongqing, Peoples R China; [Deng, Hui; Li, Tian] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Fu, Li-Juan] Chongqing Med Univ, Sch Tradit Chinese Med, Dept Herbal Med, Chongqing, Peoples R China"

通信作者："Zhong, ZH (corresponding author), Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth & Management, Dept Epidemiol,Innovat Ctr Social Risk Governance, Chongqing, Peoples R China.; Fu, LJ (corresponding author), Chongqing Med Univ, Sch Tradit Chinese Med, Dept Herbal Med, Chongqing, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000619295400009

JCR分区：Q1

影响因子：6.6

年份：2021

卷号：282

期号：　

开始页：51

结束页：57

文献类型：Article

关键词：Polycystic ovary syndrome; Anxiety; Depression; Sleep disorders

摘要："Background: Mental health disorders are highly prevalent in polycystic ovary syndrome (PCOS) cases. The etiology for anxiety/depression in women with PCOS still remains unclear, due to conflicting results. Aim: To examine whether an association exists between the mental health of Chinese women with PCOS and various indicators such as their disease characteristics, biochemistry results and sleep status. Methods: During July 2018 and January 2020, our study included a total of 433 women diagnosed with PCOS at Chongqing Hospital of Traditional Chinese Medicine. Sleep-related variables were evaluated by the Pittsburgh Sleep Quality Index (PSQI), anxiety and depression values were quantified by the Hospital Anxiety and Depression Scale (HADS), and biochemistry results were collected from the medical records of the patients. Results: 26.6% patients resulted as positive anxiety and 23.6% as positive depression. We found significant associations between anxiety/depression status and sleep conditions of PCOS patients. More specifically, anxiety significantly associated with sleep quality OR (95%CI) = 1.611 (1.147-2.261), sleep disturbance 2.326 (1.468-3.685) and daytime dysfunction 1.457 (1.122-1.891). Similarly, depression significantly associated with sleep quality 1.467 (1.043-2.063), sleep disturbance 1.624 (1.030-2.561) and daytime dysfunction 1.406 (1.077-1.836). There was no association detected between mental health and disease characteristics, as well as reproductive and metabolic indicators in PCOS. Limitation: Cross-sectional nature of the data prevents causal associations, selection bias of a hospital-based population. Conclusions: Sleep-related disorders might be involved in the etiology and development of the anxiety/depression observed in PCOS cases. We propose that management of sleep disorders should be an integral part of the disease management of women with PCOS."

基金机构：Chongqing Municipal Health Bureau Chinese Medicine Technology Project [ZY201802044]

基金资助正文：This work was supported by funds from Chongqing Municipal Health Bureau Chinese Medicine Technology Project (serial number: ZY201802044).