Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

作者全名："Li, Wenjing; Peng, Lanbo; Yang, Chao; Chen, Guangmin"

作者地址："[Li, Wenjing; Yang, Chao] Second Peoples Hosp Liaocheng, Endocrinol Dept, Liaocheng 252600, Shandong, Peoples R China; [Peng, Lanbo] Liaocheng Peoples Hosp, Endocrinol Dept, Liaocheng 252000, Shandong, Peoples R China"

通信作者："Chen, GM (corresponding author), Chongqing Med Univ, Nephrol & Urol Ctr, Univ Town Hosp, 55 Univ Town Middle Rd, Chongqing 401551, Peoples R China."

来源：DIABETOLOGY & METABOLIC SYNDROME

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000626837100001

JCR分区：Q2

影响因子：4.8

年份：2021

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：T2DM; Chronic complications; Diagnosis

摘要："Background Protein phosphatase 4 regulatory subunit 1 (PP4R1) is one of the regulatory subunits of PP4. It has been determined to be involved in the regulation of TNF-alpha-induced hepatic insulin resistance and gluconeogenesis. Considering the important role of PP4R1 in hepatic insulin resistance, the current study explored the expression and diagnostic value of PP4R1 in type 2 diabetes mellitus (T2DM) patients and further investigated its predictive value for the development of chronic complications. Method Hundred and five patients with T2DM and 97 healthy controls were collected. qRT-PCR was used for the measurement of serum PP4R1 mRNA level in both T2DM and control groups. The diagnostic value of PP4R1 in T2DM patients was evaluated using receiver operating characteristic (ROC) curve. Kaplan-Meier methods and Cox regression analysis were used to evaluate the predictive value of PP4R1 for the development of chronic complications in T2DM patients. Results PP4R1 was determined to be elevated in the serum of T2DM patients compared with healthy controls. Serum PP4R1 had the potential to distinguish T2DM patients from healthy controls with a sensitivity of 81.9% and specificity of 82.5%. Patients with high PP4R1 expression experienced more chronic complications events. The multivariate Cox analysis results suggested that serum PP4R1 expression was an independent factor for the occurrence of chronic complications for T2DM patients. Conclusion PP4R1 is elevated in the serum of T2DM patients, had the potential to distinguish T2DM patients from healthy controls. PP4R1 serves as a promising biomarker for predicting the risk of future chronic complications in T2DM patients."

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