Genomic insights into the host specific adaptation of the Pneumocystis genus

作者全名："Cisse, Ousmane H.; Ma, Liang; Dekker, John P.; Khil, Pavel P.; Youn, Jung-Ho; Brenchley, Jason M.; Blair, Robert; Pahar, Bapi; Chabe, Magali; Van Rompay, Koen K. A.; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S.; Stajich, Jason E.; Cuomo, Christina A.; Cushion, Melanie T.; Kovacs, Joseph A."

作者地址："[Cisse, Ousmane H.; Ma, Liang; Kutty, Geetha; Liu, Yueqin; Kovacs, Joseph A.] NIH, Dept Crit Care Med, Clin Ctr, Bethesda, MD 20892 USA; [Dekker, John P.; Khil, Pavel P.] NIAID, Bacterial Pathogenesis & Antimicrobial Resistance, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; [Dekker, John P.; Khil, Pavel P.; Youn, Jung-Ho] NIH, Dept Lab Med, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA; [Brenchley, Jason M.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA; [Blair, Robert; Pahar, Bapi] Tulane Univ, Tulane Natl Primate Res Ctr, New Orleans, LA 70118 USA; [Chabe, Magali] Univ Lille, CHU Lille, CIIL Ctr Infect & Immunite Lille, CNRS,Inserm,Inst Pasteur Lille,U1019,UMR 9017, Lille, France; [Van Rompay, Koen K. A.; Keesler, Rebekah] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA; [Sukura, Antti] Univ Helsinki, Fac Vet Med, Dept Vet Pathol, Helsinki, Finland; [Hirsch, Vanessa] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA; [Peng, Li; Chen, Jie] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Song, Jun; Xu, Jie] Univ Michigan, Med Ctr, Sch Med, Ctr Adv Models Translat Sci & Therapeut, Ann Arbor, MI 48109 USA; [Weissenbacher-Lang, Christiane] Univ Vet Med Vienna, Dept Pathobiol, Inst Pathol, Vienna, Austria; [Upham, Nathan S.] Arizona State Univ, Sch Life Sci, Tempe, AZ USA; [Stajich, Jason E.] Univ Calif Riverside, Dept Microbiol & Plant Pathol, Riverside, CA 92521 USA; [Stajich, Jason E.] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA; [Cuomo, Christina A.] Broad Inst Harvard & MIT, Cambridge, MA USA; [Cushion, Melanie T.] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH USA"

通信作者："Cisse, OH; Ma, L; Kovacs, JA (corresponding author), NIH, Dept Crit Care Med, Clin Ctr, Bethesda, MD 20892 USA."

来源：COMMUNICATIONS BIOLOGY

ESI学科分类：　

WOS号：WOS:000627440700002

JCR分区：Q1

影响因子：5.9

年份：2021

卷号：4

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans. Cisse, Ma et al. utilize genomic data from Pneumocystis species infecting macaques, rabbit, dogs and rats to investigate the molecular basis of host specificity in Pneumocystis. Their analyses provide insight to the specific adaptations enabling the infection of humans by P. jirovecii."

基金机构：National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA

基金资助正文：Open Access funding provided by the National Institutes of Health (NIH).