Aberrant multimodal brain networks in patients with anti-NMDA receptor encephalitis

作者全名："Wang, Jinhui; Duan, Yunyun; Zhang, Tian; Huang, Jing; Ren, Zhuoqiong; Ye, Jing; Wang, Ningkai; Li, Yinzhi; Chen, Xiaoya; Gao, Peiyi; Li, Kuncheng; Liu, Yaou"

作者地址："[Wang, Jinhui; Wang, Ningkai; Li, Yinzhi] South China Normal Univ, Ctr Studies Psychol Applicat, Guangdong Key Lab Mental Hlth & Cognit Sci, Inst Brain Res & Rehabil, Guangzhou, Peoples R China; [Wang, Jinhui] South China Normal Univ, Minist Educ, Key Lab Brain Cognit & Educ Sci, Guangzhou, Peoples R China; [Duan, Yunyun; Gao, Peiyi; Liu, Yaou] Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China; [Zhang, Tian; Huang, Jing; Ren, Zhuoqiong; Ye, Jing; Li, Kuncheng] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China; [Chen, Xiaoya] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Liu, Yaou] China Natl Clin Res Ctr Neurol Dis, Tiantan Image Res Ctr, Beijing, Peoples R China"

通信作者："Liu, YO (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China."

来源：CNS NEUROSCIENCE & THERAPEUTICS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000628344100001

JCR分区：Q1

影响因子：5.5

年份：2021

卷号：27

期号：6

开始页：652

结束页：663

文献类型：Article

关键词：anti‐ NMDAR encephalitis; brain network; cognitive impairment; lateral orbital gyrus; multimodal magnetic resonance imaging

摘要："Aims To explore large-scale brain network alterations and examine their clinical and neuropsychological relevance in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods Twenty-four patients with anti-NMDAR encephalitis and 26 matched healthy controls (HCs) were enrolled in our study. Based on the multimodal MRI dataset, individual morphological, structural, and functional brain networks were constructed and compared between the two groups at multiple levels. The associations with clinical/neuropsychological variables and the discriminant ability of significant alterations were further studied. Results Multimodal network analysis revealed that anti-NMDAR encephalitis mainly affected morphological and structural networks, but subtle alterations were observed in functional networks. Intriguingly, decreased network local efficiency was observed for both morphological and structural networks and increased nodal centrality in the lateral orbital gyrus was convergently observed among the three types of networks in the patients. Moreover, the alterations, particularly those from structural networks, accounted largely for cognitive deficits of the patients and could distinguish the diseased individuals from the HCs with excellent performance (area under the curve =0.933). Conclusions The current study provides a comprehensive view of characteristic multimodal network dysfunction in anti-NMDAR encephalitis, which is crucial to establish new diagnostic biomarkers and promising therapeutic targets for the disease."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81922036, 81671764, 81571631, 81401377]; Key-Area Research and Development Program of Guangdong Province [2019B030335001]; ECTRIMS-MAGNIMS Fellowship from The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); Beijing Natural Science fundBeijing Natural Science Foundation [7162077]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (grant numbers: 81922036, 81671764, 81571631, and 81401377), Key-Area Research and Development Program of Guangdong Province (2019B030335001), ECTRIMS-MAGNIMS Fellowship from The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (YL), and Beijing Natural Science fund (grant number: 7162077)"