"Time trends of childhood food allergy in China: Three cross-sectional surveys in 1999, 2009, and 2019"

作者全名："Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Wang, Juan; Hu, Yan"

作者地址："[Ma, Zhuoying; Wang, Juan; Hu, Yan] Chongqing Med Univ, Childrens Hosp, Dept Child Hlth Care, 136,2nd Zhongshan Rd, Chongqing, Peoples R China; [Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Wang, Juan; Hu, Yan] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Fang, Heping; Wang, Juan; Hu, Yan] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Hu, Yan] Chongqing Key Lab Child Hlth & Nutr, Chongqing, Peoples R China"

通信作者："Hu, Y (corresponding author), Chongqing Med Univ, Childrens Hosp, Dept Child Hlth Care, 136,2nd Zhongshan Rd, Chongqing, Peoples R China."

来源：PEDIATRIC ALLERGY AND IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000628873000001

JCR分区：Q1

影响因子：4.4

年份：2021

卷号：32

期号：5

开始页：1073

结束页：1079

文献类型：Article

关键词：children; cross‐ sectional study; food allergy; prevalence; time trends

摘要："Background Many countries have recorded the trends of food allergy (FA) prevalence. Little is known about epidemiologic trends of childhood FA in China. Methods In three cross-sectional surveys conducted in 1999, 2009, and 2019, the prevalence of and characteristic changes in FA in children aged <= 2 years were assessed and the outcomes were compared. All the children were recruited during well-baby check-ups at the Children's Hospital of Chongqing Medical University. All participants had a detailed medical history taken and underwent skin prick tests using ten commercial food extracts. Open food challenges were used for confirmation of FA. Results The three studies included 1228 children (314 in 1999, 401 in 2009, and 513 in 2019; response rate > 95%). The prevalence of FA in 2009 (7.7%) and 2019 (11.1%) was significantly higher than that in 1999 (3.5%). However, there was no statistically significant difference in prevalence between 2009 and 2019 (P = .086). There was evidence of increased prevalence in CMPA between 1999 and 2019 (1.6% versus 5.7%; P = .004). However, no statistic difference was found in egg allergy (2.9% versus 5.5%; P = .21). The incidence of skin symptoms did not differ significantly over the study period, while the incidence of gastrointestinal symptoms increased significantly (18.2% in 1999, 12.9% in 2009, and 43.9% in 2019; P < .05). Conclusions The prevalence of FA in children rapidly increased after the 1990s and gradually stabilized after 2010. Cow's milk has become the most common food allergen among children in Chongqing. The incidence of gastrointestinal symptoms as a manifestation of FA has increased significantly since 2010."

基金机构："Chongqing Science and Technology Commission, ChinaNatural Science Foundation Project of CQ CSTC [cstc2018jscx--msybX0038]"

基金资助正文："This study received funding from Chongqing Science and Technology Commission, China (cstc2018jscx--msybX0038)."