Chem-inspired hollow ceria nanozymes with lysosome-targeting for tumor synergistic phototherapy

作者全名："Zhou, Li; Li, Wei; Wen, Yilin; Fu, Xiaoxue; Leng, Feng; Yang, Jiaxin; Chen, Lu; Yu, Xiaojuan; Yu, Chao; Yang, Zhangyou"

作者地址："[Zhou, Li; Wen, Yilin; Fu, Xiaoxue; Leng, Feng; Yang, Jiaxin; Chen, Lu; Yu, Xiaojuan; Yu, Chao; Yang, Zhangyou] Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 400016, Peoples R China; [Li, Wei] Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China"

通信作者："Yu, C; Yang, ZY (corresponding author), Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 400016, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000629733200016

JCR分区：Q2

影响因子：7

年份：2021

卷号：9

期号：10

开始页：2515

结束页：2523

文献类型：Article

关键词：　

摘要："The precise operation of the hypoxic tumor microenvironment presents a promising way to improve treatment efficacy, in particular in tumor synergistic phototherapy. This work reports an innovative approach to build adenosine triphosphate-modified hollow ceria nanozymes (ATP-HCNPs@Ce6) that manipulate tumor hypoxia to effectively achieve drug delivery. Hollow ceria nanoparticles (HCNPs) exhibit a controllable hollow structure through varying nitric acid concentrations in the nanocomposites. Specifically, ATP modification makes HCNPs exceptionally biocompatible and stable and acts as a regulator of HCNP enzymatic activity. In the stage of drug loading, newly prepared ATP-HCNPs@Ce6 serves as an in situ oxygen-generating agent because of its ability to simulate catalase. Therefore, ATP-HCNPs@Ce6 has adjustable enzymatic properties that act like a ""switch"" to selectively supply oxygen in response to high levels of hydrogen peroxide expression and the slightly acidic lysosomal environment of the tumor to enhance lysosome-targeted photodynamic therapy. Moreover, the obvious anticancer effects of ATP-HCNPs@Ce6 are demonstrated in vitro and in vivo. Overall, a simple and rapid self-assembly strategy to form and modify multifunctional HCNPs is reported, which may further propel their application in the field of precision tumor treatment."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703156]; Chongqing Medical University [YXY2019XSZ1]

基金资助正文：This work was supported by the National Natural Science Foundation of China (81703156) and Chongqing Medical University (YXY2019XSZ1).