A clinical-radiomics nomogram may provide a personalized 90-day functional outcome assessment for spontaneous intracerebral hemorrhage

作者全名："Song, Zuhua; Tang, Zhuoyue; Liu, Huan; Guo, Dajing; Cai, Jinhua; Zhou, Zhiming"

作者地址："[Song, Zuhua; Guo, Dajing; Zhou, Zhiming] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China; [Song, Zuhua; Tang, Zhuoyue] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Radiol, Chongqing, Peoples R China; [Liu, Huan] GE Healthcare, Shanghai, Peoples R China; [Cai, Jinhua; Zhou, Zhiming] Chongqing Med Univ, Dept Radiol, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Zhou, ZM (corresponding author), Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China.; Zhou, ZM (corresponding author), Chongqing Med Univ, Dept Radiol, Childrens Hosp, Chongqing, Peoples R China."

来源：EUROPEAN RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000629876500002

JCR分区：Q1

影响因子：5.9

年份：2021

卷号：31

期号：7

开始页：4949

结束页：4959

文献类型：Article

关键词：Multidetector computed tomography; Cerebral hemorrhage; Prognosis; Nomograms

摘要："Objectives To develop and validate a noncontrast computed tomography (NCCT)-based clinical-radiomics nomogram to identify spontaneous intracerebral hemorrhage (sICH) patients with a poor 90-day prognosis on admission. Methods In this double-center retrospective study, data from 435 patients with sICH (training cohort: n = 244; internal validation cohort: n = 104; external validation cohort: n = 87) were reviewed. The radiomics score (Rad-score) was calculated based on the coefficients of the selected radiomics features. A clinical-radiomics nomogram was developed by using independent predictors of poor outcome at 90 days through multivariate logistic regression analysis in the training cohort and was validated in the internal and external cohorts. Results At 90 days, 200 of 435 (46.0%) patients had a poor prognosis. The clinical-radiomics nomogram was developed by six independent predictors namely midline shift, NCCT time from sICH onset, Glasgow Coma Scale score, serum glucose, uric acid, and Rad-score. In identifying patients with poor prognosis, the clinical-radiomics nomogram showed an area under the receiver operating characteristic curve (AUC) of 0.81 in the training cohort, an AUC of 0.78 in the internal validation cohort, and an AUC of 0.73 in the external validation cohort. The calibration curve revealed that the clinical-radiomics nomogram showed satisfactory calibration in the training and internal validation cohorts (both p > 0.05), but slightly poor agreement in the external validation cohort (p < 0.05). Conclusions The clinical-radiomics nomogram is a valid computer-aided tool that may provide personalized risk assessment of 90-day functional outcome for sICH patients."

基金机构：Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81401382]

基金资助正文：This study was supported by a grant from the Natural Science Foundation of China (81401382).