Interfacial cationization to quicken redox-responsive drug release

作者全名："Zheng, Yaxin; Lei, Jie; Li, Qi; Jin, Xuan; Li, Qingyuan; Li, Yang"

作者地址："[Zheng, Yaxin; Lei, Jie; Li, Qi; Jin, Xuan; Li, Qingyuan] Chengdu Med Coll, Sch Pharm, Key Lab Sichuan Prov Specif Struct Small Mol Drug, Chengdu, Peoples R China; [Li, Yang] Chongqing Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400016, Peoples R China"

通信作者："Li, Y (corresponding author), Chongqing Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400016, Peoples R China."

来源：CHEMICAL COMMUNICATIONS

ESI学科分类：CHEMISTRY

WOS号：WOS:000630134800022

JCR分区：Q2

影响因子：4.9

年份：2021

卷号：57

期号：23

开始页：2943

结束页：2946

文献类型：Article

关键词：　

摘要：Interfacial cationization could greatly increase the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies (NAs) due to the generation and concentration of ionized thiols at the alkalized NAs' cationic interface. This strategy could be used to prepare redox-ultrasensitive nanocarriers for efficient intracellular drug delivery.

基金机构："Foundation for New Teacher Training Program of Chongqing Medical University [YXY20 20XSZ02]; National Undergraduate Training Program for Innovation and Entrepreneurship [S202013705008, S20201370 5048, S202013705125]"

基金资助正文："This research was supported by the Foundation for New Teacher Training Program of Chongqing Medical University (YXY20 20XSZ02), and the National Undergraduate Training Program for Innovation and Entrepreneurship (S202013705008, S20201370 5048, and S202013705125)."