Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action

作者全名："Luo, Yinpei; Sun, Yuwei; Tian, Xuelong; Zheng, Xiaolin; Wang, Xing; Li, Weina; Wu, Xiaoying; Shu, Bin; Hou, Wensheng"

作者地址："[Luo, Yinpei; Sun, Yuwei; Tian, Xuelong; Zheng, Xiaolin; Wang, Xing; Wu, Xiaoying; Hou, Wensheng] Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China; [Tian, Xuelong; Zheng, Xiaolin; Wang, Xing; Wu, Xiaoying; Hou, Wensheng] Chongqing Univ, Chongqing Med Elect Engn Technol Res Ctr, Chongqing, Peoples R China; [Li, Weina] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Shu, Bin] Chongqing Med Univ, Univ Town Hosp, Dept Rehabil Med, Chongqing, Peoples R China"

通信作者："Wu, XY (corresponding author), Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China.; Wu, XY (corresponding author), Chongqing Univ, Chongqing Med Elect Engn Technol Res Ctr, Chongqing, Peoples R China."

来源：FRONTIERS IN AGING NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000632218600001

JCR分区：Q2

影响因子：4.8

年份：2021

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：deep brain stimulation; Alzheimer' s disease; therapeutic effect; stimulation parameter; action mechanism

摘要："Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by using internal pulse generators to electrodes in specific target areas of the brain. As a blind treatment, DBS is widely used in the field of mental and neurological diseases, although its mechanism of action is still unclear. In the past 10 years, DBS has shown a certain positive effect in animal models and patients with Alzheimer's disease (AD), but there are also different results that may be related to the stimulation parameters of DBS. Based on this, determining the optimal stimulation parameters for DBS in AD and understanding its mechanism of action are essential to promote the clinical application of DBS in AD. This review aims to explore the therapeutic effect of DBS in AD, and to analyze its stimulation parameters and potential mechanism of action. The keywords ""Deep brain stimulation"" and ""Alzheimer's Disease"" were used for systematic searches in the literature databases of Web of Science and PubMed (from 1900 to September 29, 2020). All human clinical studies and animal studies were reported in English, including individual case studies and long-term follow-up studies, were included. These studies described the therapeutic effects of DBS in AD. The results included 16 human clinical studies and 14 animal studies, of which 28 studies clearly demonstrated the positive effect of DBS in AD. We analyzed the current stimulation parameters of DBS in AD from stimulation target, stimulation frequency, stimulation start time, stimulation duration, unilateral/bilateral treatment and current intensity, etc., and we also discussed its potential mechanism of action from multiple aspects, including regulating related neural networks, promoting nerve oscillation, reducing beta-amyloid and tau levels, reducing neuroinflammation, regulating the cholinergic system, inducing the synthesis of nerve growth factor."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31872751, 31771069, 31971287]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (31872751, 31771069, and 31971287)."