Integrin-alpha 9 beta 1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights

作者全名："Xu, Shihan; Zhang, Tingwei; Cao, Zhengguo; Zhong, Wenjie; Zhang, Chuangwei; Li, Han; Song, Jinlin"

作者地址："[Xu, Shihan; Zhang, Tingwei; Zhong, Wenjie; Zhang, Chuangwei; Li, Han; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Xu, Shihan; Zhang, Tingwei; Zhong, Wenjie; Zhang, Chuangwei; Li, Han; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Xu, Shihan; Zhang, Tingwei; Zhong, Wenjie; Zhang, Chuangwei; Li, Han; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing, Peoples R China; [Cao, Zhengguo] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Minist Educ, Wuhan, Peoples R China; [Cao, Zhengguo] Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan, Peoples R China; [Cao, Zhengguo] Wuhan Univ, Sch & Hosp Stomatol, Dept Periodontol, Wuhan, Peoples R China"

通信作者："Song, JL (corresponding author), Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China.; Song, JL (corresponding author), Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Song, JL (corresponding author), Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000634102300001

JCR分区：Q1

影响因子：7.3

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：integrin-α 9β 1; cancer; autoimmune diseases; axon regeneration; thrombosis

摘要："Integrins refer to heterodimers consisting of subunits alpha and beta. They serve as receptors on cell membranes and interact with extracellular ligands to mediate intracellular molecular signals. One of the least-studied members of the integrin family is integrin-alpha 9 beta 1, which is widely distributed in various human tissues and organs. Integrin-alpha 9 beta 1 regulates the physiological state of cells through a variety of complex signaling pathways to participate in the specific pathological processes of some intractable diseases. In recent years, an increasing amount of research has focused on the role of alpha 9 beta 1 in the molecular mechanisms of different refractory diseases and its promising potential as a therapeutic target. Accordingly, this review introduces and summarizes recent research related to integrin-alpha 9 beta 1, describes the synergistic functions of alpha 9 beta 1 and its corresponding ligands in cancer, autoimmune diseases, nerve injury and thrombosis and, more importantly, highlights the potential of alpha 9 beta 1 as a distinctive target for the treatment of these intractable diseases."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771082, 31971282, 81800985]; Chongqing Graduate Tutor Team"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant Nos. 81771082, 31971282, 81800985) and the Chongqing Graduate Tutor Team (2019)."