Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

作者全名："Zhao, Xia; Hu, Daniel A.; Wu, Di; He, Fang; Wang, Hao; Huang, Linjuan; Shi, Deyao; Liu, Qing; Ni, Na; Pakvasa, Mikhail; Zhang, Yongtao; Fu, Kai; Qin, Kevin H.; Li, Alexander J.; Hagag, Ofir; Wang, Eric J.; Sabharwal, Maya; Wagstaff, William; Reid, Russell R.; Lee, Michael J.; Wolf, Jennifer Moriatis; El Dafrawy, Mostafa; Hynes, Kelly; Strelzow, Jason; Ho, Sherwin H.; He, Tong-Chuan; Athiviraham, Aravind"

作者地址："[Zhao, Xia; Zhang, Yongtao] Qingdao Univ, Dept Orthpaed Surg, Affiliated Hosp, Qingdao, Peoples R China; [Zhao, Xia; Hu, Daniel A.; Wu, Di; He, Fang; Wang, Hao; Huang, Linjuan; Shi, Deyao; Liu, Qing; Ni, Na; Pakvasa, Mikhail; Zhang, Yongtao; Fu, Kai; Qin, Kevin H.; Li, Alexander J.; Hagag, Ofir; Wang, Eric J.; Sabharwal, Maya; Wagstaff, William; Reid, Russell R.; Lee, Michael J.; Wolf, Jennifer Moriatis; El Dafrawy, Mostafa; Hynes, Kelly; Strelzow, Jason; Ho, Sherwin H.; He, Tong-Chuan; Athiviraham, Aravind] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA; [He, Fang; Huang, Linjuan] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 1, Chongqing, Peoples R China; [He, Fang; Huang, Linjuan] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China; [Wang, Hao; Ni, Na] Chongqing Med Univ, Sch Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China; [Shi, Deyao] Huazhong Univ Sci & Technol, Union Hosp, Dept Orthpaed Surg, Tongji Med Coll, Wuhan, Peoples R China; [Liu, Qing] Cent South Univ, Xiangya Hosp 2, Dept Spine Surg, Changsha, Peoples R China; [Fu, Kai] Wuhan Univ, Dept Neurosurg, Affiliated Zhongnan Hosp, Wuhan, Peoples R China; [Reid, Russell R.] Univ Chicago, Med Ctr, Dept Surg, Sect Plast Surg, Chicago, IL 60637 USA"

通信作者："He, TC; Athiviraham, A (corresponding author), Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000637551800001

JCR分区：Q1

影响因子：5.7

年份：2021

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：articular cartilage; chondrocytes; stem cells; cartilage tissue engineering; scaffold materials; biocompatibility; osteoarthritis

摘要："Cartilage, especially articular cartilage, is a unique connective tissue consisting of chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in maintaining joint durability and mobility by providing nearly frictionless articulation for mechanical load transmission between joints. Damage to the articular cartilage frequently results from sport-related injuries, systemic diseases, degeneration, trauma, or tumors. Failure to treat impaired cartilage may lead to osteoarthritis, affecting more than 25% of the adult population globally. Articular cartilage has a very low intrinsic self-repair capacity due to the limited proliferative ability of adult chondrocytes, lack of vascularization and innervation, slow matrix turnover, and low supply of progenitor cells. Furthermore, articular chondrocytes are encapsulated in low-nutrient, low-oxygen environment. While cartilage restoration techniques such as osteochondral transplantation, autologous chondrocyte implantation (ACI), and microfracture have been used to repair certain cartilage defects, the clinical outcomes are often mixed and undesirable. Cartilage tissue engineering (CTE) may hold promise to facilitate cartilage repair. Ideally, the prerequisites for successful CTE should include the use of effective chondrogenic factors, an ample supply of chondrogenic progenitors, and the employment of cell-friendly, biocompatible scaffold materials. Significant progress has been made on the above three fronts in past decade, which has been further facilitated by the advent of 3D bio-printing. In this review, we briefly discuss potential sources of chondrogenic progenitors. We then primarily focus on currently available chondrocyte-friendly scaffold materials, along with 3D bioprinting techniques, for their potential roles in effective CTE. It is hoped that this review will serve as a primer to bring cartilage biologists, synthetic chemists, biomechanical engineers, and 3D-bioprinting technologists together to expedite CTE process for eventual clinical applications."

基金机构：National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA226303]; Medical Scientist Training Program of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [T32 GM007281]; University of Chicago Cancer Center Support Grant [P30CA014599]; National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [5UL1TR002389-02]; SHOCK Fund at The University of Chicago; Mabel Green Myers Research Endowment Fund; University of Chicago Orthopaedics Alumni Fund

基金资助正文："The reported work was supported in part by a research grant from the National Institutes of Health (CA226303 to T-CH). WW was supported by the Medical Scientist Training Program of the National Institutes of Health (T32 GM007281). This project was also supported in part by The University of Chicago Cancer Center Support Grant (P30CA014599) and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) through Grant Number 5UL1TR002389-02 that funds the Institute for Translational Medicine (ITM) although the contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. SH and T-CH were supported by the SHOCK Fund at The University of Chicago, and T-CH was also supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund. Funding sources were not involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication."