LncRNA SNHG19 Promotes the Development of Non-Small Cell Lung Cancer via Mediating miR-137/E2F7 Axis

作者全名："Zhao, Guang-Yin; Ning, Zhao-Feng; Wang, Rui"

作者地址："[Zhao, Guang-Yin] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Thorac Surg, Sch Med, Shanghai, Peoples R China; [Ning, Zhao-Feng] Canc Hosp, Radiotherapy Branch, Tai An, Shandong, Peoples R China; [Wang, Rui] Chongqing Med Univ, Dept Thorac Surg, Affiliated Hosp 3, Chongqing, Peoples R China"

通信作者："Wang, R (corresponding author), Chongqing Med Univ, Dept Thorac Surg, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000637729000001

JCR分区：Q2

影响因子：4.7

年份：2021

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：non-small cell lung cancer (NSCLC); long non-coding RNA (LncRNA) SNHG19; MiR-137; tumorigenesis

摘要："Objective Non-small cell lung cancer (NSCLC) is a common malignant tumor, which has high incidence and low the 5-year survival rate. Long non-coding RNAs (lncRNAs) play critical roles in carcinoma occurrence and metastasis. Herein, our aim was to investigate the effects of lncRNA SNHG19 in NSCLC progression. Materials and Methods Long non-coding RNA Small Nucleolar RNA Host Gene 19 (lncRNA SNHG19) expression level was measured by bioinformatics and qRT-PCR. Edu, Transwell, and scratch assays were performed to explore the role of si-SNHG19 or SNHG19 on NSCLC progression. Luciferase assay was used to verify the relationship between SNHG19/E2F7 and miR-137. The experiment of Xenograft was used for exploring the function of SNHG19 in vivo. Results SNHG19 was upregulated in cancer tissues, patients plasma and cell lines of NSCLC. Knockdown of SNHG19 inhibited cell proliferation, migration, and invasion. Luciferase assay confirmed that SNHG19 regulated E2F7 expression via interacting with miR-137. Overexpression of SNHG19 accelerated NSCLC tumor progression via miR-137/E2F7 axis both in vitro and in vivo. Conclusions Our results clarified the SNHG19 function for the first time, and SNHG19 promoted the progression of NSCLC, which was mediated by the miR-137/E2F7 axis. This study might provide new understanding and targets for NSCLC diagnosis and treatment."

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