Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet's Uveitis

作者全名："Pei, Minghang; Liu, Xinshu; Yang, Peizeng; Zhao, Chan; Gao, Fei; Qu, Yi; Liang, Anyi; Xiao, Junyan; Zhang, Meifen"

作者地址："[Pei, Minghang] Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou, Peoples R China; [Liu, Xinshu] Fourth Peoples Hosp Shenyang, Dept Ophthalmol, Shenyang, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Ocular Dis, Chongqing Key Lab Ophthalmol,Chongqing Eye Inst,C, Chongqing, Peoples R China; [Zhao, Chan; Gao, Fei; Qu, Yi; Liang, Anyi; Xiao, Junyan; Zhang, Meifen] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing, Peoples R China"

通信作者："Zhang, MF (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000639559400001

JCR分区：Q1

影响因子：7.3

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Behcet’ s disease; Behcet’ s uveitis; uveitis; gene polymorphism; single nucleotide polymorphism; interleukin 33; ST2

摘要："Interleukin (IL)33, a member of the IL1 superfamily, functions as a nuclear factor and mediates biological effects by interacting with the ST2 receptor. Recent studies have described IL33 as an emerging pro-inflammatory cytokine in the immune system, and IL33/ST2 gene polymorphisms have been implicated in the pathogenesis of various immune diseases. However, the underlying mechanisms of IL33/ST2 in Behcet's disease (BD) remain to be defined. Here, we investigated the association between IL33/ST2 gene polymorphisms and BD in 585 BD uveitis (BDU) patients and 834 healthy controls using Agena MassARRAY iPLEX platform. We found that rs3821204 was associated with the development of BDU. Moreover, the frequency of rs2210463 G allele was lower in patients with genital involvement. Association analysis revealed a much greater genetic difference between complete-type and incomplete-type BD groups, including three SNPs (rs7044343, rs1048274, and rs2210463). Our findings suggest that IL33/ST2 gene polymorphisms are involved in the pathogenesis of BDU. Different genetic backgrounds may exist in complete-type and incomplete-type BD patients."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770917]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z171100001017217]

基金资助正文："This work was supported by the National Natural Science Foundation of China [81770917] (fees for patient enrollment, carrying out the experimental work and open access publication) and Beijing Municipal Science and Technology Commission No. Z171100001017217 (fees for patient enrollment)."