Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8+T cell-mediated antitumor responses in mice

作者全名："Pan, Jianhua; Ma, Meng; Qin, Li; Kang, Zhongkui; Adah, Dickson; Tao, Zhu; Li, Xiaofen; Dai, Linglin; Zhao, Siting; Chen, Xiaoping; Zhou, Qin"

作者地址："[Pan, Jianhua; Ma, Meng; Zhou, Qin] Chongqing Med Univ, Coll Lab Med, Key Lab Lab Med Diagnost, Minist Educ, 1st Yixueyuan Rd, Chongqing 400016, Peoples R China; [Pan, Jianhua; Ma, Meng; Adah, Dickson; Li, Xiaofen; Dai, Linglin; Zhao, Siting; Chen, Xiaoping] Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, 190 Kaiyuan Ave,Guangzhou Sci Pk, Guangzhou 510530, Peoples R China; [Pan, Jianhua; Ma, Meng; Adah, Dickson; Li, Xiaofen; Dai, Linglin; Zhao, Siting; Chen, Xiaoping] Chinese Acad Sci, Guangzhou Inst Hlth, State Key Lab Resp Dis, 190 Kaiyuan Ave,Guangzhou Sci Pk, Guangzhou 510530, Peoples R China; [Qin, Li; Kang, Zhongkui; Tao, Zhu] CAS Lamvac Biotech Co Ltd, 3 LanYue Rd Sci Pk, Guangzhou 510663, Peoples R China"

通信作者："Zhou, Q (corresponding author), Chongqing Med Univ, Coll Lab Med, Key Lab Lab Med Diagnost, Minist Educ, 1st Yixueyuan Rd, Chongqing 400016, Peoples R China.; Chen, XP (corresponding author), Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, 190 Kaiyuan Ave,Guangzhou Sci Pk, Guangzhou 510530, Peoples R China.; Chen, XP (corresponding author), Chinese Acad Sci, Guangzhou Inst Hlth, State Key Lab Resp Dis, 190 Kaiyuan Ave,Guangzhou Sci Pk, Guangzhou 510530, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000641396000006

JCR分区：Q1

影响因子：7.5

年份：2021

卷号：138

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Plasmodium infection; Triple negative breast cancer; Granzyme B; Immune checkpoints; CD8+T cells

摘要："We previously reported that Plasmodium infection promotes antitumor immunity in a murine Lewis lung cancer. In this study, we investigated the effects of Plasmodium infection on the tumor inhibition and antitumor CD8+ T cell responses in a murine triple negative breast cancer (TNBCA) model. The results showed that Plasmodium infection significantly inhibited tumor growth, and increased the survival rate of the tumor-bearing mice. Both effector and memory CD8+ T cells were increased in peripheral blood and tumor-draining lymph node (DLN) in the infected mice. The co-stimulatory (CD40L, GITR and OX-40) and co-inhibitory (PD-1, CTLA-4, TIM-3, LAG3) immune checkpoints were up-regulated on CD8+ T cells in infected mice. Importantly, Py induced remarkable effects on the infiltration of CD8+ T cells in the tumor and granzym B+ CD8+ T cells in tumor-bearing mice while not in tumor-free mice. In summary, the results suggested that the effects of Plasmodium infection on murine 4T1 breast cancer might be related to the induction of CD8+ T cell-mediated antitumor immune responses. This finding may provide a novel strategy for the treatment of triple negative breast cancer."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572076, 81873932]"

基金资助正文：This study was supported by the National Natural Science Foundation of China (Project numbers: 81572076 and 81873932) .