Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

作者全名："Wang, Dan; Chen, Fengjiao; Zeng, Tao; Tang, Qingxia; Chen, Bing; Chen, Ling; Dong, Yan; Li, Xiaosong"

作者地址："[Wang, Dan; Tang, Qingxia; Chen, Bing] Peoples Hosp Rongchang Dist, Dept Clin Lab, Chongqing 402460, Rongchang, Peoples R China; [Wang, Dan; Chen, Fengjiao; Chen, Ling] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing 400016, Peoples R China; [Zeng, Tao] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Chengdu 611731, Sichuan, Peoples R China; [Dong, Yan; Li, Xiaosong] Chongqing Med Univ, Clin Mol Med Testing Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Li, XS (corresponding author), Chongqing Med Univ, Clin Mol Med Testing Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000644364000006

JCR分区：Q1

影响因子：6.8

年份：2021

卷号：8

期号：2

开始页：157

结束页：167

文献类型：Review

关键词：ceRNAs; HCC; lncRNAs; miRNAs; ncRNAs; snoRNAs

摘要："Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new moleculartargeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871653]; Program for Innovation Team of Higher Education in Chongqing [CXTDX201601015]; Natural Science Foundation of ChongqingNatural Science Foundation of Chongqing [cstc2016jcyjA0269]

基金资助正文："This study was supported by the National Natural Science Foundation of China (grant number 81871653), the Program for Innovation Team of Higher Education in Chongqing (grant number CXTDX201601015) and the Natural Science Foundation of Chongqing (grant number cstc2016jcyjA0269). The authors are grateful to the study participants."