Eriodictyol inhibits glioblastoma migration and invasion by reversing EMT via downregulation of the P38 MAPK/GSK-3 beta/ZEB1 pathway

作者全名："Lv, Feng; Du, Qian; Li, Lin; Xi, Xin; Liu, Qinglong; Li, Wenjun; Liu, Songqing"

作者地址："[Lv, Feng; Du, Qian; Li, Lin; Xi, Xin; Liu, Qinglong; Li, Wenjun; Liu, Songqing] Chongqing Med Univ, Gener Hosp, Affiliated Hosp 3, Dept Pharm, Chongqing 401120, Peoples R China"

通信作者："Li, WJ; Liu, SQ (corresponding author), Chongqing Med Univ, Gener Hosp, Affiliated Hosp 3, Dept Pharm, Chongqing 401120, Peoples R China."

来源：EUROPEAN JOURNAL OF PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000647724400003

JCR分区：Q1

影响因子：5

年份：2021

卷号：900

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Eriodictyol; Glioblastoma; EMT; Migration; Invasion; Network pharmacology

摘要："Eriodictyol (ERD) is a natural flavonoid that exists in many vegetables and fruits, especially citrus fruits. It has been proven to have many pharmacological effects, such as antioxidative, anti-inflammatory and neuroprotective effects. Our previous study showed that eriodictyol could inhibit the proliferation and induce the apoptosis of glioblastoma cells by downregulating the PI3K/Akt/NF-?B pathway and restraining its migration and invasion. However, the mechanism by which eriodictyol prevents glioblastoma metastasis is still unknown. Epithelial?mesenchymal transition (EMT) is a key process for many cancer metastases; it also confers locomotivity to tumor cells, including glioblastoma. In this study, we found that eriodictyol can suppress the migration and invasion of glioblastoma A172 and U87 MG cell lines by suppressing the EMT markers ? N-cadherin and Ecadherin through Wound healing and Transwell assays, Western blot, RT-qPCR, immunofluorescence and immunohistochemistry. Further research revealed that the mechanism could be connected with downregulation of the P38 MAPK/GSK-313/ZEB1 signaling pathway. These findings can provide a new idea for the treatment of glioblastoma."

基金机构："Natural Science Foundation of Chongqing, ChinaNatural Science Foundation of Chongqing [cstc2020jcyj-msxmX0371]"

基金资助正文："This research was sponsored by the Natural Science Foundation of Chongqing, China. (No. cstc2020jcyj-msxmX0371)."