Investigating two distinct dummy templates molecularly imprinted polymers as paclitaxel adsorbent in synthesis system and releaser in biological samples

作者全名："Ling-Tan; Yang, Li-Li; Li, Yan-Jun; Jiang, Zhuang-Fei; Li, Qing-Yao; Ma, Rong-Rong; He, Jia-Yuan; Zhou, Lian-Di; Zhang, Qi-Hui; Yuan, Chun-Su"

作者地址："[Ling-Tan; Yang, Li-Li; Li, Yan-Jun; Jiang, Zhuang-Fei; Li, Qing-Yao; Ma, Rong-Rong; He, Jia-Yuan; Zhang, Qi-Hui] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China; [Zhou, Lian-Di] Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China; [Ling-Tan] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 400044, Peoples R China; [Zhang, Qi-Hui; Yuan, Chun-Su] Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA; [Zhang, Qi-Hui; Yuan, Chun-Su] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA"

通信作者："Zhang, QH (corresponding author), Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China.; Zhou, LD (corresponding author), Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China."

来源：MICROCHEMICAL JOURNAL

ESI学科分类：CHEMISTRY

WOS号：WOS:000647794000005

JCR分区：Q1

影响因子：4.8

年份：2021

卷号：165

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Dummy template molecularly imprinted; polymer; Paclitaxel; 10-Deacetylbaccatin III; Fecal sample of cancer patient; Side chain of paclitaxel

摘要："Two distinct new dummy-template molecularly imprinted polymers (D-MIPs) for selective extraction of paclitaxel (PTX) were prepared by the bulk polymerization approach using 10-deacetylbaccatin III (10-DAB) and the side chain (SC) of PTX as the template molecules individually. The obtained D-MIPs exhibited high adsorption capacity and high selectivity: 10-DAB-MIPs for PTX 15.48 mg/g and SC-MIPs for PTX 19.23 mg/g. Under the optimum experimental conditions, both 10-DAB-MIPs and SC-MIPs could be successfully applied to enrich PTX from its structural analogs and acted as a drug vehicle for delivering therapy. For example, 10-DAB-MIPs and SCMIPs were used as PTX carriers, and the carriers were incubated with artificial gastric juice, artificial intestinal fluid, and patient fecal samples. PTX was detected in samples with an elution rate of about 45%, indicating that the two D-MIPs were good vehicles for delivering PTX in the intestine. The results showed that these D-MIPs had great potential to be used as adsorbing materials for PTX and for drug delivery systems in complex biological systems."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973451]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2019CDYGYB027, 2019CDXYHG0013, 2017CDJXFLX0014]; Fundamental and Frontier Research Fund of Chongqing [cstc2018jcyjAX0661]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZDK201800103]; Graduate research and innovation foundation of Chongqing, China [CYS18033]; Venture & Innovation Support Program for Chongqing Overseas Returnees; Tang Foundations"

基金资助正文："~ This work was supported by National Natural Science Foundation of China (Grant No. 81973451) ; Fundamental Research Funds for the Central Universities (Grant No. 2019CDYGYB027, 2019CDXYHG0013 and 2017CDJXFLX0014) ; Fundamental and Frontier Research Fund of Chongqing (Grant No. cstc2018jcyjAX0661) ; Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJZDK201800103) ; Graduate research and innovation foundation of Chongqing, China (Grant No. CYS18033) ; Venture & Innovation Support Program for Chongqing Overseas Returnees, and Tang Foundations."