Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism
作者全名："Zeng, Fanyu; Wang, Dandan; Tian, Yan; Wang, Min; Liu, Rui; Xia, Zhining; Huang, Yike"
作者地址："[Zeng, Fanyu; Wang, Dandan; Tian, Yan; Wang, Min; Liu, Rui; Xia, Zhining] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Huang, Yike] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"
通信作者："Xia, ZN (corresponding author), Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China.; Huang, YK (corresponding author), Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."
来源：JOURNAL OF PHARMACEUTICAL SCIENCES
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
WOS号：WOS:000652025100028
JCR分区：Q2
影响因子：3.8
年份：2021
卷号：110
期号：6
开始页：2555
结束页：2561
文献类型：Article
关键词：Nanodrug; Intestinal absorption; Hesperetin; Bioavailability; Pharmacokinetics
摘要："This study aimed to prepare a nanoemulsion vehicle to improve the oral bioavailability of hesperetin. The pseudo-ternary phase diagrams and the RSM were used to optimize nanoemulsion parameters. Compared with hesperetin suspension, the AUC0-t and Cmax of nanoemulsion were increased by 5.67-fold and 2.64-fold, respectively. The proportion of lymphatic transport reached 87.72%, the cumulative absorption amount of jejunum, ileum, and duodenum increased by 1.1-fold, 1.92-fold, and 1.5-fold, respectively. The results implied that hesperetin nanoemulsion could effectively improve the bioavailability of hesperetin by increasing lymphatic transport and enhancing intestinal permeability. Therefore, nanoemulsion is a potential method to improve the bioavailability of hesperetin, which has strong practicability.& nbsp; (c) 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved."
基金机构：National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21974015]
基金资助正文："This work was supported by the National Natural Science Foundation of China (NSFC, No. 21974015) ."
