The Effect of Statin Treatment on Outcomes of Cardioembolic Stroke: A Systematic Review and Meta-Analysis of Real-World Studies

作者全名："Xu, Tao; Wang, You; Yuan, Jinxian; Chen, Yangmei"

作者地址："[Xu, Tao; Wang, You; Yuan, Jinxian; Chen, Yangmei] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Chen, YM (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：CNS DRUGS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000652961900003

JCR分区：Q1

影响因子：6

年份：2021

卷号：35

期号：7

开始页：717

结束页：726

文献类型：Review

关键词：　

摘要："Background Several real-world observational studies have investigated the association between statin treatment and outcomes of cardioembolic stroke. However, substantial uncertainties remain about this association. Objective We aimed to perform a systematic review and meta-analysis to determine the effect of statin treatment on the outcomes of cardioembolic stroke. Methods We systematically searched the PubMed and Embase databases for relevant clinical studies. Pooled relative risks (RRs) and 95% confidence intervals (CIs) with a random-effects model were used to assess the outcomes of interest. Results A total of 18 observational studies published between 2009 and 2020 were included. No randomized clinical trial was found. Compared with non-statin treatment, statin treatment was not associated with a decreased risk of stroke recurrence in patients with cardioembolic stroke [PWCS] (RR, 0.93; 95% CI 0.82-1.06). However, compared with non-statin treatment, statin treatment was associated with a lower risk of all-cause death (RR, 0.59; 95% CI 0.49-0.73) and better functional outcomes (RR, 0.67; 95% CI 0.47-0.97) in PWCS. There was no significant association between statin treatment and major bleeding event risk in PWCS (RR, 0.35; 95% CI 0.06-2.16). Compared with non-statin treatment, statin treatment was not associated with a decreased risk of coronary atherosclerotic disease in PWCS (RR, 1.04; 95% CI 0.96-1.11). Conclusions Although the use of statins does not enhance the prevention of stroke recurrence in PWCS, statin treatment is associated with improved clinical outcomes in PWCS. Statins play a beneficial role in the treatment of cardioembolic stroke."

基金机构："National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81901315, 81771390]"

基金资助正文：This study was supported by the National Science Foundation of China (no. 81901315 and no. 81771390).