"Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer"

作者全名："Li, Zheng-Yan; Wang, Jin-Tao; Chen, Gang; Shan, Zhi-Guo; Wang, Ting-Ting; Shen, Yang; Chen, Jun; Yan, Zong-Bao; Peng, Liu-Sheng; Mao, Fang-Yuan; Teng, Yong-Sheng; Liu, Jin-Shan; Zhou, Yuan-Yuan; Zhao, Yong-Liang; Zhuang, Yuan"

作者地址："[Li, Zheng-Yan; Wang, Jin-Tao; Chen, Gang; Shan, Zhi-Guo; Chen, Jun; Yan, Zong-Bao; Zhao, Yong-Liang] Third Mil Med Univ, Southwest Hosp, Dept Gen Surg, Chongqing 400038, Peoples R China; [Li, Zheng-Yan; Wang, Jin-Tao; Chen, Gang; Shan, Zhi-Guo; Chen, Jun; Yan, Zong-Bao; Zhao, Yong-Liang] Third Mil Med Univ, Southwest Hosp, Ctr Minimal Invas Gastrointestinal Surg, Chongqing 400038, Peoples R China; [Wang, Ting-Ting] Chongqing Med Univ, Dept Pharmacol, Chongqing Key Res Lab Drug Metab, Chongqing, Peoples R China; [Shen, Yang] North Sichuan Med Coll, Dept Oncol, Affiliated Hosp, Nanchong, Sichuan, Peoples R China; [Peng, Liu-Sheng; Mao, Fang-Yuan; Teng, Yong-Sheng; Zhuang, Yuan] Third Mil Med Univ, Coll Pharm & Lab Med, Natl Engn Res Ctr Immunol Prod, Dept Microbiol & Biochem Pharm, Chongqing 400038, Peoples R China; [Liu, Jin-Shan] Chongqing Med Univ, Dept Gen Surg, Affiliated Hosp 1, Qijiang Hosp, Chongqing, Peoples R China; [Zhou, Yuan-Yuan] Third Mil Med Univ, XinQiao Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China; [Zhuang, Yuan] Southwest Med Univ, Dept Gastroenterol, Affiliated Hosp, Luzhou 64600, Sichuan, Peoples R China"

通信作者："Zhao, YL (corresponding author), Third Mil Med Univ, Southwest Hosp, Dept Gen Surg, Chongqing 400038, Peoples R China.; Zhao, YL (corresponding author), Third Mil Med Univ, Southwest Hosp, Ctr Minimal Invas Gastrointestinal Surg, Chongqing 400038, Peoples R China.; Zhuang, Y (corresponding author), Third Mil Med Univ, Coll Pharm & Lab Med, Natl Engn Res Ctr Immunol Prod, Dept Microbiol & Biochem Pharm, Chongqing 400038, Peoples R China.; Zhou, YY (corresponding author), Third Mil Med Univ, XinQiao Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China.; Zhuang, Y (corresponding author), Southwest Med Univ, Dept Gastroenterol, Affiliated Hosp, Luzhou 64600, Sichuan, Peoples R China."

来源：CLINICAL IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000655700000010

JCR分区：Q1

影响因子：8.6

年份：2021

卷号：227

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Gastric cancer; Neutrophils; B7-H3; Granulocyte-macrophage colony stimulating; factor

摘要："Neutrophils are conspicuous components of gastric cancer (GC) tumors, increasing with tumor progression and poor patient survival. However, the phenotype, regulation and clinical relevance of neutrophils in human GC are presently unknown. Most intratumoral neutrophils showed an activated CD54+ phenotype and expressed high level B7-H3. Tumor tissue culture supernatants from GC patients induced the expression of CD54 and B7-H3 on neutrophils in time-dependent and dose-dependent manners. Locally enriched CD54+ neutrophils and B7-H3+ neutrophils positively correlated with increased granulocyte-macrophage colony stimulating factor (GM-CSF) detection ex vivo; and in vitro GM-CSF induced the expression of CD54 and B7-H3 on neutrophils in both timedependent and dose-dependent manners. Furthermore, GC tumor-derived GM-CSF activated neutrophils and induced neutrophil B7-H3 expression via JAK-STAT3 signaling pathway activation. Finally, intratumoral B7-H3+ neutrophils increased with tumor progression and independently predicted reduced overall survival. Collectively, these results suggest B7-H3+ neutrophils to be potential biomarkers in GC."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81902922, 81872016]; Chongqing National Science Fund for Distinguished Young Scholars [cstc2019jcyjjqX0003]; Science Innovation Capacity Promotion Project of Army Medical University [2019XQY03]; National Key Research and Development Program of China [2016YFC1302200]"

基金资助正文：This work was supported by National Natural Science Foundation of China (81902922 and 81872016) and Chongqing National Science Fund for Distinguished Young Scholars (cstc2019jcyjjqX0003) and Science Innovation Capacity Promotion Project of Army Medical University (2019XQY03) and National Key Research and Development Program of China (2016YFC1302200).