"Autophagic dysfunction of beta cell dysfunction in type 2 diabetes, a double-edged sword"

作者全名：Ding Yao; Yang GangYi; Wu QiNan

作者地址："[Ding Yao; Wu QiNan] Chongqing Univ, Endocrinol & Nephrol Dept, Canc Hosp, Chongqing 400030, Peoples R China; [Ding Yao; Wu QiNan] Chongqing Canc Inst, Chongqing 400030, Peoples R China; [Ding Yao; Wu QiNan] Chongqing Canc Hosp, Chongqing 400030, Peoples R China; [Yang GangYi] Chongqing Med Univ, Affiliated Hosp 2, Endocrinol Dept, Chongqing 400010, Peoples R China"

通信作者："Wu, QA (corresponding author), Chongqing Univ, Endocrinol & Nephrol Dept, Canc Hosp, Chongqing 400030, Peoples R China.; Wu, QA (corresponding author), Chongqing Canc Inst, Chongqing 400030, Peoples R China.; Wu, QA (corresponding author), Chongqing Canc Hosp, Chongqing 400030, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000661449300005

JCR分区：Q1

影响因子：6.8

年份：2021

卷号：8

期号：4

开始页：438

结束页：447

文献类型：Review

关键词：Apoptosis; Autophagic dysfunction; Insulin resistance; Islet beta cell dysfunction; Type 2 diabetes mellitus

摘要："Diabetes is an age-related disease, most of which is type 2 diabetes, and islet beta cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370885]; Research Institute performance incentive and guidanceproject of Chongqing Science and Technology Bureau [cstc2019jxjl130006]; General program of Natural Science Foundation of Chongqing Science and Technology Bureau [cstc2019jcyjmsxm0827]; 2019 Merck Diabetes Research Fund [gx2019056]

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (grant number 81370885) , Research Institute performance incentive and guidanceproject of Chongqing Science and Technology Bureau (grant number cstc2019jxjl130006) , General program of Natural Science Foundation of Chongqing Science and Technology Bureau (grant number cstc2019jcyjmsxm0827) , 2019 Merck Diabetes Research Fund (grant number gx2019056) ."