Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury

作者全名："Lin, Yong; Yuan, Jun; Long, Quanxin; Hu, Jieli; Deng, Haijun; Zhao, Zhenyu; Chen, Juan; Lu, Mengji; Huang, Ailong"

作者地址："[Lin, Yong; Long, Quanxin; Hu, Jieli; Deng, Haijun; Zhao, Zhenyu; Chen, Juan; Huang, Ailong] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Chinese Minist Educ, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Yuan, Jun] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China; [Lu, Mengji] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45122 Essen, Germany"

通信作者："Huang, AL (corresponding author), Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Chinese Minist Educ, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Lu, MJ (corresponding author), Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45122 Essen, Germany."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000661449300009

JCR分区：Q1

影响因子：6.8

年份：2021

卷号：8

期号：4

开始页：484

结束页：492

文献类型：Article

关键词：Abnormal liver function; COVID-19; HBV; Inactive HBV carriers; Liver injury; SARS-CoV-2

摘要："To date, it remains unclear if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection exacerbates liver injury in patients with chronic hepatitis B virus (HBV) infection. In this study, we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019 (COVID-19) cases, including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19. We found that there were no significant differences for the discharge rate or duration of hospitalization between the two groups. However, inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests. The enhanced liver injury induced by SARS-CoV2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type. Moreover, the inflammatory response, including abnormal lactate dehydrogenase, D-dimer and interleukin-6 production, may contribute to this injury following SARS-CoV-2 co-infection. Collectively, SARS-CoV-2 and HBV co-infection exacerbates liver function of the patients with COVID-19. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V."

基金机构："Major National S&T Program from Science & Technology Commission of China [2017ZX10202203, 2017ZX10302201]; Emergency Project from the Science & Technology Commission of Chongqing [cstc2020jscx-fyzx0053]; Natural Science Foundation Project of CQ CSTCNatural Science Foundation Project of CQ CSTC [cstc2020jcyj-msxmX0081]; Venture and Innovation Support Program for Chongqing Overseas Returnees [cx2019114]; COVID-19 Emergency Project [CQMUNCP0207]; Scientific Research Staring Foundation of Chongqing Medical University from Chongqing Medical University [X9729]"

基金资助正文："This work was supported by the Major National S&T Program (grant numbers 2017ZX10202203 and 2017ZX10302201) from Science & Technology Commission of China, the Emergency Project (grant number cstc2020jscx-fyzx0053) from the Science & Technology Commission of Chongqing, the Natural Science Foundation Project of CQ CSTC (grant number cstc2020jcyj-msxmX0081), the Venture and Innovation Support Program for Chongqing Overseas Returnees (grant number cx2019114), the COVID-19 Emergency Project (grant number CQMUNCP0207) and the Scientific Research Staring Foundation of Chongqing Medical University (grant number X9729) from Chongqing Medical University."