Identification of a nomogram based on an 8-lncRNA signature as a novel diagnostic biomarker for childhood acute lymphoblastic leukemia

作者全名："Chen, Zhang; Yang, Fan; Liu, Hui; Fan, Fan; Lin, Yanggang; Zhou, Jinhua; Cai, Yun; Zhang, Xiaoxiao; Wu, Yingxin; Mao, Rui; Zhang, Tongtong"

作者地址："[Chen, Zhang; Lin, Yanggang; Zhou, Jinhua; Mao, Rui; Zhang, Tongtong] Southwest Jiaotong Univ, Affiliated Hosp, Chengdu 610036, Peoples R China; [Yang, Fan] Peking Univ, Hosp 3, Emergency Dept, Sch Med, Beijing 100083, Peoples R China; [Liu, Hui; Fan, Fan] Gen Hosp Western Theater Command, Dept Neurol, Chengdu 610500, Peoples R China; [Cai, Yun] Gen Hosp Western Theater Command, Dept Orthoped, Chengdu 610083, Peoples R China; [Zhang, Xiaoxiao] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China; [Zhang, Xiaoxiao] Sichuan Univ, West China Hosp 4, Chengdu 610041, Peoples R China; [Wu, Yingxin; Mao, Rui; Zhang, Tongtong] Southwest Jiaotong Univ, Ctr Gastrointestinal & Minimally Invas Surg, Dept Gen Surg, Peoples Hosp Chengdu 3,Affiliated Hosp, Chengdu 610031, Peoples R China; [Wu, Yingxin; Mao, Rui; Zhang, Tongtong] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China"

通信作者："Mao, R; Zhang, TT (corresponding author), Southwest Jiaotong Univ, Affiliated Hosp, Chengdu 610036, Peoples R China.; Wu, YX; Mao, R; Zhang, TT (corresponding author), Southwest Jiaotong Univ, Ctr Gastrointestinal & Minimally Invas Surg, Dept Gen Surg, Peoples Hosp Chengdu 3,Affiliated Hosp, Chengdu 610031, Peoples R China.; Wu, YX; Mao, R; Zhang, TT (corresponding author), Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000662870500012

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：13

期号：11

开始页：15548

结束页：15568

文献类型：Article

关键词：childhood acute lymphoblastic leukemia; prognosis; nomogram; LINC01278; hsa-miR-500b

摘要："Childhood acute lymphoblastic leukemia (cALL) still represents a major cause of disease-related death in children. This study aimed to explore the prognostic value of long non-coding RNAs (lncRNAs) in cALL. We downloaded lncRNA expression profiles from the TARGET and GEO databases. Univariate, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analyses were applied to identify lncRNA-based signatures. We identified an eight-lncRNA signature (LINC00630, HDAC2-AS2, LINC01278, AL356599.1, AC114490.1, AL132639.3, FUT8.AS1, and TTC28.AS1), which separated the patients into two groups with significantly different overall survival rates. A nomogram based on the signature, BCR ABL1 status and white blood cell count at diagnosis was developed and showed good accuracy for predicting the 3-, 5- and 7-year survival probability of cALL patients. The C-index values of the nomogram in the training and internal validation set reached 0.8 (95% CI, 0.757 to 0.843) and 0.806 (95% CI, 0.728 to 0.884), respectively. The nomogram proposed in this study objectively and accurately predicted the prognosis of cALL. In vitro experiments suggested that LINC01278 promoted the proliferation of leukemic cells and inhibited leukemic cell apoptosis by targeting the inhibition of miR-500b-3p in cALL, and LINC01278 may be a biological target for the treatment of cALL in the future."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502075]; Foundation of Science and Technology of Sichuan Province [2019YJ0635]

基金资助正文：The study here was supported by grants from the National Natural Science Foundation of China (81502075) and the Foundation of Science and Technology of Sichuan Province (2019YJ0635) . The funders did not take part in the design and implementation.