In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice

作者全名："Mu, Xinyi; Tu, Zhihan; Chen, Xuemei; Hong, Yi; Geng, Yanqing; Zhang, Yan; Ji, Xingduo; Liu, Taihang; Wang, Yingxiong; He, Junlin"

作者地址："[Mu, Xinyi; Geng, Yanqing; Liu, Taihang; Wang, Yingxiong] Chongqing Med Univ, Coll Basic Med, Chongqing, Peoples R China; [Mu, Xinyi; Tu, Zhihan; Chen, Xuemei; Hong, Yi; Geng, Yanqing; Zhang, Yan; Ji, Xingduo; Liu, Taihang; Wang, Yingxiong; He, Junlin] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Tu, Zhihan; Chen, Xuemei; Hong, Yi; Zhang, Yan; Ji, Xingduo; He, Junlin] Chongqing Med Univ, Sch Publ Hlth & Management, Lab Reprod Biol, Chongqing, Peoples R China; [Tu, Zhihan] Chengdu Ctr Dis Control & Prevent, Chengdu, Peoples R China; [Ji, Xingduo] Chenghua Dist Ctr Dis Control & Prevent, Chengdu, Peoples R China"

通信作者："He, JL (corresponding author), Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China.; He, JL (corresponding author), Chongqing Med Univ, Sch Publ Hlth & Management, Lab Reprod Biol, Chongqing, Peoples R China."

来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000662989700001

JCR分区：Q1

影响因子：5.5

年份：2021

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：estrogen; meiotic prophase I; homologous recombination; oocytes; ovarian follicle; estrogen receptor 2

摘要："The association between the accumulation of synthetic chemicals with estrogenic activity and risks to oogenesis has become a growing concern. This study indicates that in utero estrogen exposure can affect homologous recombination in early oogenesis and influence the reproductive potential and lifespan of female offspring. We conducted this study in developing mouse ovaries using two different models: oral doses administered to the mother, and fetal ovary cultures. Our analyses of meiotic fetal oocytes suggest that 17-beta-estradiol induces gross aberrations in prophase I events, including delayed meiotic progression, increased unrepaired DNA damage, and altered homologous recombination levels. These effects were mainly mediated by estrogen receptor 2 (ESR2) activation. Mid-gestation exposure to estrogen also led to delayed primordial folliculogenesis after birth, impaired follicle development after prepuberty, and ultimately reduced the total litter size of the offspring. This raises the concern that maternal exposures to substances activating ESR2 may compromise the fertility of the exposed female fetus."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [32070851, 31601200]; Natural Science Foundation of ChongqingNatural Science Foundation of Chongqing [cstc2020jcyj-msxmX0135]"

基金资助正文：This work was supported by the grants from the National Natural Science Foundation of China (32070851 and 31601200) and Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0135).