Ginsenosides in vascular remodeling: Cellular and molecular mechanisms of their therapeutic action

作者全名："Zhu, Guang-Xuan; Zuo, Jian-Li; Xu, Lin; Li, Shu-Qing"

作者地址："[Zhu, Guang-Xuan] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China; [Zuo, Jian-Li] Chongqing Med Univ, Coll Pharm, Chongqing 410016, Peoples R China; [Xu, Lin] Zunyi Med Univ, Coll Pharm, Zunyi 563000, Guizhou, Peoples R China; [Li, Shu-Qing] Cent South Univ, Shenzhen Hosp, Xiangya Hosp 2, Shenzhen 518067, Guangdong, Peoples R China"

通信作者："Zhu, GX (corresponding author), Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China."

来源：PHARMACOLOGICAL RESEARCH

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000663005100034

JCR分区：Q1

影响因子：9.3

年份：2021

卷号：169

期号：　

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结束页：　

文献类型：Review

关键词：Cardiovascular disease; Endothelial cells; Ginsenosides; Smooth muscle cells; Vascular remodeling

摘要："Evidence is mounting that abnormal vascular remodeling (VR) is a vital pathological event that precedes many cardiovascular diseases (CVD). This provides us with a new research perspective that VR can be a pivotal target for CVD treatment and prevention. However, the current drugs for treating CVD do not fundamentally reverse VR and repair vascular function. The reason may be that a complicated regulatory network is formed between the various signaling pathways involved in VR. Recently, ginsenoside, the main active substance of ginseng, has become increasingly the focus of many researchers for its multiple targets, multiple pathways, and few side effects. Several data have revealed that ginsenosides can improve VR caused by vasodilation dysfunction, abnormal vascular structure and blood pressure. This review is intended to discuss the therapeutic effects and mechanisms of ginsenosides in some diseases involved in VR. Besides, we herein also give a new and contradictory insight into intracellular and molecular signaling of ginsenosides in all kinds of vascular cells. Most importantly, we also discuss the feasibility of ginsenosides Rb1/Rg1/Rg3 in drug development by combining the pharmacodynamics and pharmacokinetics of ginsenosides, and provide a pharmacological basis for the development of ginsenosides in clinical applications."

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