PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53

作者全名："Wang, Wuyi; Wei, Jinlai; Zhang, Hairong; Zheng, Xiangru; Zhou, He; Luo, Yajun; Yang, Jianguo; Deng, Qican; Huang, Siqi; Fu, Zhongxue"

作者地址："[Wang, Wuyi; Wei, Jinlai; Zhang, Hairong; Zheng, Xiangru; Zhou, He; Luo, Yajun; Yang, Jianguo; Deng, Qican; Huang, Siqi; Fu, Zhongxue] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing, Peoples R China"

通信作者："Fu, ZX (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing, Peoples R China."

来源：CELL DEATH & DISEASE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000663552600003

JCR分区：Q1

影响因子：9

年份：2021

卷号：12

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Colorectal cancer is the most common gastrointestinal cancer and causes severe damage to human health. PRDX2 is a member of the peroxiredoxin family reported to have a high level of expression in colorectal cancer. However, the mechanisms by which PRDX2 promotes the proliferation of colorectal cancer are still unclear. Here, the results indicated that PRDX2 expression was upregulated in colorectal cancer and closely correlated with poor prognosis. Functionally, PRDX2 promoted the proliferation of colorectal cancer cells. Mechanistically, PRDX2 could bind RPL4, reducing the interaction between RPL4 and MDM2. These findings demonstrate that the oncogenic property of PRDX2 may be attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572319]; Chongqing Natural Science FoundationNatural Science Foundation of Chongqing [cstc2017jcyjAX0127]

基金资助正文：The research project was supported by the National Natural Science Foundation of China (Grant No. 81572319; Project recipient: F.Z.) and Chongqing Natural Science Foundation (Grant No. cstc2017jcyjAX0127; Project recipient: W.J.).