"Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer"

作者全名："Yuan, Chendong; Chen, Mingxiang; Cai, Xiaolu"

作者地址："[Yuan, Chendong] Shaoxing Univ, Zhuji Affiliated Hosp, Dept Vasc Surg, Zhuji 311800, Zhejiang, Peoples R China; [Chen, Mingxiang] Chongqing Med Univ, Affiliated Hosp 3, Dept Cardiovasc Surg, Chongqing 401120, Yubei, Peoples R China; [Cai, Xiaolu] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Surg Oncol, Hangzhou 310003, Peoples R China"

通信作者："Chen, MX (corresponding author), Chongqing Med Univ, Affiliated Hosp 3, Dept Cardiovasc Surg, Chongqing 401120, Yubei, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000663682000004

JCR分区：Q1

影响因子：7.5

年份：2021

卷号：139

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Cancer; PCBP2; Function; Molecular mechanisms; Biomarker; Therapeutics

摘要："Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. PCBP2 contains three K homology domains, which are consensus RNA-binding domains that play a role in recognizing and combining with RNA and DNA. The specific structure and localization of PCBP2 lay the foundation for its multiple roles in transcriptional, posttranscriptional, and translational processes, even in iron metabolism. Numerous studies have indicated that PCBP2 expression is increased in many cancer types. PCBP2 is considered as an oncogene that promotes tumorigenesis, development of cancer cells, and metastasis. Here, we summarized the current evidence regarding PCBP2 in the proliferation, migration, invasion of cancer cells, and drug resistance, aiming to clarify the molecular mechanisms of PCBP2 in cancer. Results from this review suggest that an in-depth study of PCBP2 in cancer may provide novel biomarkers for prognostic or therapeutic purposes."

基金机构：Zhejiang Natural Science FoundationNatural Science Foundation of Zhejiang Province [LQ18H160012]

基金资助正文：This work was supported by Zhejiang Natural Science Foundation (LQ18H160012).