Se@Albumin nanoparticles ameliorate intestinal mucositis caused by cisplatin via gut microbiota-targeted regulation

作者全名："Deng, Liping; Zeng, Hongliang; Hu, Xueying; Xiao, Mengqing; He, Dong; Zhang, Yao; Jin, Yi; Hu, Yibo; Zhu, Yuxing; Gong, Lian; Wang, Zhanwang; Xiang, Liang; Zhu, Rongrong; Zhang, Yeyu; Cheng, Yaxin; Chen, Xingyu; Zhang, Shuihan; Peng, Yongbo; Cao, Ke"

作者地址："[Deng, Liping; Hu, Xueying; Xiao, Mengqing; Zhang, Yao; Jin, Yi; Zhu, Yuxing; Gong, Lian; Wang, Zhanwang; Xiang, Liang; Zhu, Rongrong; Zhang, Yeyu; Cheng, Yaxin; Chen, Xingyu; Cao, Ke] Cent South Univ, Dept Oncol, Xiangya Hosp 3, Changsha 410013, Peoples R China; [Zeng, Hongliang; Zhang, Shuihan] Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha 410013, Peoples R China; [He, Dong] Second Peoples Hosp Hunan Prov, Dept Resp, Changsha 410007, Peoples R China; [Hu, Yibo] Cent South Univ, Dept Dermatol, Xiangya Hosp 3, Changsha 410013, Peoples R China; [Peng, Yongbo] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Cao, K (corresponding author), Cent South Univ, Dept Oncol, Xiangya Hosp 3, Changsha 410013, Peoples R China.; Peng, YB (corresponding author), Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：NANOSCALE

ESI学科分类：PHYSICS

WOS号：WOS:000663886600001

JCR分区：Q1

影响因子：6.7

年份：2021

卷号：13

期号：25

开始页：11250

结束页：11261

文献类型：Article

关键词：　

摘要："Chemotherapy-associated intestinal mucositis is still one of the major challenges in the first-line clinical cancer treatment. Selenium element has shown health benefits on enteritis upon uptake in trace amounts; however, it was limited because of its narrow safety margin. In this work, a new form of Se@Albumin complex nanoparticles (Se@Albumin NPs) was developed by self-assembly of denatured human serum albumin and selenite salts. Se@Albumin NPs significantly improve intestinal mucositis induced with cisplatin (CDDP) in a mouse model via attenuating the level of intestinal oxidative stress, reducing intestinal permeability, and relieving gastric dysmotility. It is very interesting that the restoration of anti-inflammatory bacteria (Bacteroidetes and Firmicutes) and reduced abundance of proinflammatory bacteria (Escherichia) contributed to the reduction of intestinal mucositis by Se@Albumin NPs in mice. In addition, the fecal microbiota transplantation (FMT) with materials from Se@Albumin NP-treated mice significantly protected pseudo-aseptic mice from CDDP-induced intestinal mucositis. In conclusion, our findings showed that Se@Albumin NPs can significantly improve CDDP-induced intestinal mucositis, and its function may be directly mediated by gut microbiota regulation, which will provide new helpful information for clinical treatment."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874137]; Outstanding Youth Foundation of Hunan Province [2018JJ1047]; Hunan Province Science and Technology Talent Promotion Project [2019TJ-Q10]; Key Research and Development Project of Hunan Province [2019NK2101]; Natural Science Foundation Project of Changsha [kq2007063]; Science and Technology Innovation Program of Hunan Province [2020RC4011]; Young Scholars of "Furong Scholar Program" in Hunan Province; Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University [BJ202001]; Independent Exploration and Innovation Project of Central South University [2020zzts897]

基金资助正文："The work was supported by National Natural Science Foundation of China (81874137), Outstanding Youth Foundation of Hunan Province (2018JJ1047), Hunan Province Science and Technology Talent Promotion Project (2019TJ-Q10), Key Research and Development Project of Hunan Province (2019NK2101), Natural Science Foundation Project of Changsha (kq2007063), Science and Technology Innovation Program of Hunan Province (2020RC4011), Young Scholars of ""Furong Scholar Program"" in Hunan Province, the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University (BJ202001) and the Independent Exploration and Innovation Project of Central South University (2020zzts897)."