Nanotube-decorated hierarchical tantalum scaffold promoted early osseointegration

作者全名："Zhang, Zhiyi; Li, Yuzhou; He, Ping; Liu, Fengyi; Li, Lingjie; Zhang, He; Ji, Ping; Yang, Sheng"

作者地址："[Zhang, Zhiyi; Li, Yuzhou; He, Ping; Liu, Fengyi; Li, Lingjie; Zhang, He; Ji, Ping; Yang, Sheng] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Zhang, Zhiyi; Li, Yuzhou; He, Ping; Liu, Fengyi; Li, Lingjie; Zhang, He; Ji, Ping; Yang, Sheng] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Zhang, Zhiyi; Li, Yuzhou; He, Ping; Liu, Fengyi; Li, Lingjie; Zhang, He; Ji, Ping; Yang, Sheng] Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing, Peoples R China"

通信作者："Zhang, H; Ji, P; Yang, S (corresponding author), Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China."

来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000664181600001

JCR分区：Q1

影响因子：5.4

年份：2021

卷号：35

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Tantalum; Scaffold; Osseointegration; Osteogenesis

摘要："This study aimed to fabricate a hierarchical tantalum scaffold mimicking natural bone structure to enhance osseointegration. Porous tantalum scaffolds (p-Ta) with microgradients were fabricated by selective laser melting according to a computer-aided design model. Electrochemical anodization produced nanotubes on the p-Ta surface (p-Ta-nt). SEM verified the construction of a unique nanostructure on p-Ta-nt. Contact angle and protein adsorption measurements demonstrated that p-Ta-nt have enhanced hydrophilicity and protein absorption. MC3T3-E1 preosteoblasts showed increased filamentous pseudopods and comparable cell proliferation when cultured on p-Ta-nt. Osteogenic marker gene (Osterix, Runx2, COL-I) transcription was significantly upregulated in MC3T3-E1 cells cultured on p-Ta-nt after 7 days. After implantation into the femurs of New Zealand white rabbits for 2 weeks, histological examination found improved early osseointegration in the p-Ta-nt group. This study showed that a hierarchical tantalum structure could enhance early osteogenic effects in vitro and in vivo. (c) 2021 Elsevier Inc. All reserved."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500894, 81901057]; Basic Research and Frontier Exploration Grant of Chongqing Science and Technology Commission (Natural Science Foundation of Chongqing) [cstc2019jcyj-msxmX0366]; Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN201900441]; Major Program of Chongqing Yuzhong District [20190103]; Yubei District Science Project [2018GY11]; Chongqing Postgraduate Tutor Team Construction Project [dstd201806]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant No. 81500894, 81901057); the Basic Research and Frontier Exploration Grant of Chongqing Science and Technology Commission (Natural Science Foundation of Chongqing, Grant No. cstc2019jcyj-msxmX0366); the Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No. KJQN201900441); the Major Program of Chongqing Yuzhong District (Grant No. 20190103); Yubei District Science Project [2018GY11]; and the Chongqing Postgraduate Tutor Team Construction Project (Grant No. dstd201806)."