Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD

作者全名："Zhang, Jing; Li, Gang; Laukkanen, Jari A.; Liu, Cheng; Song, Xing; Zhu, Yuqi"

作者地址："[Zhang, Jing; Li, Gang; Liu, Cheng; Song, Xing; Zhu, Yuqi] Chongqing Med Univ, Dept Geriatr, Div Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Laukkanen, Jari A.] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland; [Laukkanen, Jari A.] Univ Eastern Finland, Inst Clin Med, Dept Med, Kuopio, Finland; [Laukkanen, Jari A.] Cent Finland Hlth Care Dist, Dept Med, Jyvaskyla, Finland"

通信作者："Li, G (corresponding author), Chongqing Med Univ, Dept Geriatr, Div Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000667449400011

JCR分区：Q1

影响因子：4.6

年份：2021

卷号：11

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac atrial and ventricular dimensions according to severity of lung functional impairment in Chinese COPD elderly. A total of 563 hospitalized COPD patients with lung function impairment and 184 patients with non-COPD (aged 65-92 years) were collected retrospectively in a cross-sectional study in a university affiliated tertiary hospital in China. BMI and cardiac echocardiographic parameters were compared according to severity of lung functional impairment in COPD patients. BMI was 22.9 +/- 3.9 kg/m(2) in COPD patients, 24.0 +/- 4.1 kg/m(2) in non-COPD patients respectively. Reduced BMI, LV mass index, LV wall thickness and left atrial diameter, and dilated right ventricle (RV) existed in COPD patients with severe lung dysfunction as compared the COPD patients with mild to moderate lung functional reduction and non-COPD patients (P<0.05), while there were no differences in BMI and echocardiographic parameters between the COPD patients with mild to moderate lung functional decline and non-COPD patients (P>0.05). Logistic regression analysis showed that low BMI (BMI<18.5 kg/m(2)) was correlated with reduced LV mass and wall thickness, dilated RV and reduced lung function in the COPD patients with severe lung dysfunction. In conclusion, this study demonstrates that lower BMI is associated not only with dilated RV and impaired pulmonary function, but also it is related to reduced LV mass in Asian COPD elderly with severe lung dysfunction."

基金机构："medical science & technology research fund of Health Bureau of Chongqing City, China [04-2-154, 2009-2-290]; natural science research fund of Chongqing Science & Technology Commission in Chongqing City, China (CSTC) [2007BB5276]"

基金资助正文："This study was supported by the medical science & technology research fund of Health Bureau of Chongqing City, China (No. 04-2-154 and No. 2009-2-290) and the natural science research fund of Chongqing Science & Technology Commission in Chongqing City, China (CSTC, No. 2007BB5276)."