A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children

作者全名："Hou, Ling; Li, Xiuzhen; Liu, Li; Wei, Hanyang; Xiong, Feng; Du, Hongwei; Yang, Yu; Zhang, Huifeng; Zhang, Qin; Yao, Hui; Fu, Junfen; Yan, Xiaoli; Cui, Lanwei; Liu, Geli; Li, Tang; Chen, Shaoke; Li, Pin; Xin, Ying; Liang, Xiangrong; Yu, Baosheng; Dong, Zhiya; Chen, Ruimin; Ma, Huamei; Cheng, Xinran; Luo, Feihong; Gong, Chunxiu; Song, Wenhui; Chen, Xiaobo; Zhang, Zhixin; Peng, Xiangyun; Li, Guimei; Liang, Liyang; Maimaiti, Mireguli; Cheung, Pik To; Luo, Xiaoping"

作者地址："[Hou, Ling; Luo, Xiaoping] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Pediat, Tongji Med Coll, Wuhan, Peoples R China; [Li, Xiuzhen; Liu, Li] Guangzhou Med Univ, Dept Genet & Endocrinol, Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China; [Wei, Hanyang] Henan Prov Childrens Hosp, Dept Endocrinol & Genet, Zhengzhou, Peoples R China; [Xiong, Feng] Chongqing Med Univ, Dept Endocrine & Genet Metab Dis, Childrens Hosp, Chongqing, Peoples R China; [Du, Hongwei] Jilin Univ, Affiliated Hosp 1, Dept Pediat, Changchun, Peoples R China; [Yang, Yu] Nanchang Univ, Childrens Hosp, Dept Endocrinol Metab & Genet, Nanchang, Jiangxi, Peoples R China; [Yang, Yu] Jiangxi Prov Childrens Hosp, Nanchang, Jiangxi, Peoples R China; [Zhang, Huifeng] Hebei Med Univ, Affiliated Hosp 2, Dept Pediat, Shijiazhuang, Hebei, Peoples R China; [Zhang, Qin] Shenzhen Childrens Hosp, Dept Endocrinol, Shenzhen, Peoples R China; [Yao, Hui] Wuhan Childrens Hosp, Dept Endocrinol, Wuhan, Peoples R China; [Fu, Junfen] Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China; [Yan, Xiaoli] Xian Childrens Hosp, Dept Pediat Endocrinol, Xian, Peoples R China; [Cui, Lanwei] Harbin Med Univ, Affiliated Hosp 1, Dept Pediat, Harbin, Peoples R China; [Liu, Geli] Tianjin Med Univ, Gen Hosp, Dept Pediat, Tianjin, Peoples R China; [Li, Tang] Qingdao Univ, Qingdao Women & Childrens Hosp, Dept Pediat, Qingdao, Peoples R China; [Chen, Shaoke] Guangxi Med Univ, Affiliated Hosp 2, Dept Pediat, Nanning, Peoples R China; [Li, Pin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Endocrinol, Shanghai, Peoples R China; [Xin, Ying] China Med Univ, Dept Pediat Endocrinol, Shengjing Hosp, Shenyang, Peoples R China; [Liang, Xiangrong] Shandong Univ, Qilu Childrens Hosp, Dept Endocrinol, Jinan, Peoples R China; [Yu, Baosheng] Nanjing Med Univ, Affiliated Hosp 2, Dept Pediat, Nanjing, Peoples R China; [Dong, Zhiya] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Pediat, Shanghai, Peoples R China; [Chen, Ruimin] Fuzhou Childrens Hosp, Dept Endocrinol, Fuzhou, Peoples R China; [Ma, Huamei] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pediat, Guangzhou, Peoples R China; [Cheng, Xinran] Chengdu Womens & Childrens Cent Hosp, Dept Endocrinol & Metab, Chengdu, Peoples R China; [Luo, Feihong] Fudan Univ, Dept Pediat Endocrinol & Inherited Metab Dis, Childrens Hosp, Shanghai, Peoples R China; [Gong, Chunxiu] Beijing Childrens Hosp, Dept Med Genet, Beijing Diabet Ctr Children & Adolescents, Endocrinol Genet & Metab, Beijing, Peoples R China; [Song, Wenhui] Shanxi Prov Childrens Hosp, Dept Pediat Endocrinol, Taiyuan, Peoples R China; [Chen, Xiaobo] Capital Inst Pediat, Childrens Hosp, Dept Endocrinol, Beijing, Peoples R China; [Zhang, Zhixin] China Japan Friendship Hosp, Dept Pediat, Beijing, Peoples R China; [Peng, Xiangyun] Hunan Prov Childrens Hosp, Dept Endocrinol, Changsha, Peoples R China; [Li, Guimei] Shandong Prov Hosp, Dept Pediat, Jinan, Peoples R China; [Liang, Liyang] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pediat, Guangzhou, Peoples R China; [Maimaiti, Mireguli] Xinjiang Med Univ, Affiliated Hosp 1, Dept Pediat, Urumqi, Peoples R China; [Cheung, Pik To] Univ Hong Kong, Hong Kong, Peoples R China; [Cheung, Pik To] Virtus Med Grp, Paediat Endocrinol Genet & Metab, Hong Kong, Peoples R China"

通信作者："Luo, XP (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Dept Pediat, Tongji Med Coll, Wuhan, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000667664400001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：type 1 diabetes; children; insulin; education; survey; diabetic ketoacidosis

摘要："Purpose To investigate the features and treatment status of children with type 1 diabetes mellitus (T1DM) in China. Methods We recruited patients Results A total of 1,603 children (755 males and 848 females) with T1DM participated in this survey. Of these, 834 (52.03%) of the patients exhibited diabetic ketoacidosis (DKA) at onset, while 769 patients (47.97%) did not exhibit DKA (non-DKA) at onset. There was a higher proportion of females (55.71%) in the cohort of patients exhibiting DKA at onset than in the non-DKA cohort (49.33%). The mean age of patients exhibiting DKA at presentation was 7.12 +/- 0.14 years; this was significantly younger than that in non-DKA group (7.79 +/- 0.15 years; P < 0.005). The frequency of DKA in 3 years old, 3-7 years old, and 7 years old or more was 77.21%, 26.17%, and 37.62%, respectively. Upon initial diagnosis, 29.4%, 15.2% and 11.8% of patients showed positivity for glutamic acid decarboxylase antibody (GADA), Insulin autoantibodies (IAA), or islet cell antibody (ICA), respectively. During six months follow-up, 244 patients (15.21%) reported receiving insulin pump therapy, and more than 60% of patients monitored their blood glucose levels less than 35 times per week. Although the majority of patients had no problems with obtaining insulin, 4.74% of the children surveyed were not able to receive insulin due to financial reasons, a shortage of insulin preparations, or the failure of the parents or guardians to acquire the appropriate medicine. Conclusion DKA is more common in very young children. Treatment and follow-up of T1DM in China still face very serious challenges."

基金机构：World Diabetes Foundation [WDF11-617]; Ministry of Science and Technology [2017ZX09304022]

基金资助正文：This research was supported by grants from the World Diabetes Foundation (reference: WDF11-617) and the Ministry of Science and Technology (reference: 2017ZX09304022).