Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency

作者全名："Ren, Ziyu; Wang, Yunting; Chen, Qing; Long, Jiangchuan; Zhang, Rui; Wu, Xun; Qian, Wenjie; Chen, Yue; Liu, Dongfang; Ren, Wei"

作者地址："[Ren, Ziyu; Chen, Qing; Long, Jiangchuan; Zhang, Rui; Liu, Dongfang] Chongqing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Yunting; Wu, Xun; Qian, Wenjie; Ren, Wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Chongqing, Peoples R China; [Chen, Yue] 958 Hosp Peuples Liberat Army, Gen Practice, Chongqing, Peoples R China"

通信作者："Liu, DF (corresponding author), Chongqing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Chongqing, Peoples R China.; Ren, W (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000668109300001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：adult growth hormone deficiency; mesencephalic astrocyte-derived neurotrophic factor; insulin resistance; lipid metabolism; cardiovascular risk

摘要："Objective Adult growth hormone deficiency (AGHD) is a rare chronic inflammatory disease caused by damage to the pituitary gland and is accompanied by disorders of multiple metabolic pathways. By examining the correlation between the serum mesencephalic astrocyte-derived neurotrophic factor (MANF) levels of AGHD patients and those of normal controls, we hope to elucidate the close relationship among MANF, lipid metabolism and insulin resistance in AGHD and discuss the potential therapeutic value of MANF. Methods This study included 101 AGHD patients and 100 healthy subjects matched for sex, age, height, and weight. Anthropometric parameters and biochemical indicators such as body mass index, waist circumference, hip circumference, serum MANF level, blood lipids and insulin level were measured. The above patients were also divided into several subgroups for correlation analysis based on indicators such as insulin resistance and BMI. Results The serum circulating MANF content of AGHD patients was significantly lower than that of the normal control group (5.235 (0.507-17.62) ng/ml (n=101) vs. 10.30 (1.84-16.65) ng/ml (n=100); p<0.0001), and circulating MANF levels were linearly correlated with HOMA-IR in the AGHD population (R=0.481, P=0.0041). When MANF was at pathological concentrations (lower than the mean circulating MANF of normal controls), the lowest concentration tertile (OR=21.429 p<0.0001) had a significantly higher disease odds ratio, Framingham risk score and 10-year risk of atherosclerotic cardiovascular disease than the highest concentration tertile. Conclusions MANF has a significant correlation with insulin resistance in the AGHD state. There is a strong correlation with abnormal glucose and lipid metabolism in the obese AGHD population. MANF is also a good assessment factor for the risk of cardiovascular disease in AGHD patients and has excellent therapeutic potential."

基金机构：Project of the Science and Technology Committee in Chongqing [cstc2016jcyjA0025]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370467]

基金资助正文：This research was supported by the Project of the Science and Technology Committee in Chongqing 2016 (Number: cstc2016jcyjA0025) and the National Natural Science Foundation of China (Grant No. 81370467 to DL).