Shaping Immune Responses in the Tumor Microenvironment of Ovarian Cancer

作者全名："Luo, Xin; Xu, Jing; Yu, Jianhua; Yi, Ping"

作者地址："[Luo, Xin; Xu, Jing; Yi, Ping] Chongqing Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Yu, Jianhua] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 90068 USA; [Yu, Jianhua] City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 90068 USA"

通信作者："Xu, J; Yi, P (corresponding author), Chongqing Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Yu, JH (corresponding author), City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 90068 USA.; Yu, JH (corresponding author), City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 90068 USA."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000670252200001

JCR分区：Q1

影响因子：7.3

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：ovarian cancer; tumor microenvironment; immune; genetic; epigenetic; cytokine

摘要："Reciprocal signaling between immune cells and ovarian cancer cells in the tumor microenvironment can alter immune responses and regulate disease progression. These signaling events are regulated by multiple factors, including genetic and epigenetic alterations in both the ovarian cancer cells and immune cells, as well as cytokine pathways. Multiple immune cell types are recruited to the ovarian cancer tumor microenvironment, and new insights about the complexity of their interactions have emerged in recent years. The growing understanding of immune cell function in the ovarian cancer tumor microenvironment has important implications for biomarker discovery and therapeutic development. This review aims to describe the factors that shape the phenotypes of immune cells in the tumor microenvironment of ovarian cancer and how these changes impact disease progression and therapy."

基金机构：　

基金资助正文：