Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

作者全名："Sun, Wuping; Luo, Yixuan; Zhang, Fei; Tang, Shuo; Zhu, Tao"

作者地址："[Sun, Wuping] Shenzhen Univ, Hlth Sci Ctr, Shenzhen Nanshan Peoples Hosp, Dept Pain Med, Shenzhen, Peoples R China; [Sun, Wuping] Shenzhen Univ, Hlth Sci Ctr, Shenzhen Nanshan Peoples Hosp, Shenzhen Municipal Key Lab Pain Med, Shenzhen, Peoples R China; [Sun, Wuping; Luo, Yixuan; Zhang, Fei] Shenzhen Univ, Hlth Sci Ctr, Affiliated Hosp 6, Shenzhen, Peoples R China; [Luo, Yixuan; Zhang, Fei] Shenzhen Univ, Hlth Sci Ctr, Shenzhen Nanshan Peoples Hosp, Dept Cardiovasc Surg, Shenzhen, Peoples R China; [Tang, Shuo] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Orthopaed, Shenzhen, Peoples R China; [Zhu, Tao] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China"

通信作者："Tang, S (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 8, Dept Orthopaed, Shenzhen, Peoples R China.; Zhu, T (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China."

来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000670571500001

JCR分区：Q1

影响因子：5.5

年份：2021

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：TRP channels; calcium; thermogenesis; energy metabolism; brown adipocytes; beige adipocytes; obesity

摘要："Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81700741]; Medical Science and Technology Foundation of Guangdong [A2020600]; Science and Technology Project of Shenzhen [20190808300180]; Shenzhen Municipal Science, Technology and Innovation Commission [JCYJ20180302144710880]; Chongqing Health Joint Medical Research Project [2020MSXM112]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (No. 81700741), Medical Science and Technology Foundation of Guangdong (A2020600), the Science and Technology Project of Shenzhen (No. 20190808300180), Shenzhen Municipal Science, Technology and Innovation Commission (No. JCYJ20180302144710880), and Chongqing Health Joint Medical Research Project (No. 2020MSXM112)."