Functions and Mechanisms of Lysine Glutarylation in Eukaryotes

作者全名："Xie, Longxiang; Xiao, Yafei; Meng, Fucheng; Li, Yongqiang; Shi, Zhenyu; Qian, Keli"

作者地址："[Xie, Longxiang; Xiao, Yafei; Meng, Fucheng; Li, Yongqiang; Shi, Zhenyu] Henan Univ, Inst Biomed Informat, Henan Prov Engn Ctr Tumor Mol Med,Sch Basic Med S, Bioinformat Ctr,Cell Signal Transduct Lab,Huaihe, Kaifeng, Peoples R China; [Qian, Keli] Chongqing Med Univ, Infect Control Dept, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Shi, ZY (corresponding author), Henan Univ, Inst Biomed Informat, Henan Prov Engn Ctr Tumor Mol Med,Sch Basic Med S, Bioinformat Ctr,Cell Signal Transduct Lab,Huaihe, Kaifeng, Peoples R China.; Qian, KL (corresponding author), Chongqing Med Univ, Infect Control Dept, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000670574500001

JCR分区：Q1

影响因子：5.5

年份：2021

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：glutarylation; SIRT5; glutaryl-CoA; PTM; proteomic

摘要："Lysine glutarylation (Kglu) is a newly discovered post-translational modification (PTM), which is considered to be reversible, dynamic, and conserved in prokaryotes and eukaryotes. Recent developments in the identification of Kglu by mass spectrometry have shown that Kglu is mainly involved in the regulation of metabolism, oxidative damage, chromatin dynamics and is associated with various diseases. In this review, we firstly summarize the development history of glutarylation, the biochemical processes of glutarylation and deglutarylation. Then we focus on the pathophysiological functions such as glutaric acidemia 1, asthenospermia, etc. Finally, the current computational tools for predicting glutarylation sites are discussed. These emerging findings point to new functions for lysine glutarylation and related enzymes, and also highlight the mechanisms by which glutarylation regulates diverse cellular processes."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82002172]; Program for Science and Technology Development in Henan Province [202102310205, 192102310350, 192102310379]; Key Scientific Research Project Plan of Henan Province [20A180001]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020M682279]; Henan University Medical National Natural Science Foundation Cultivation Program"

基金资助正文："This study was funded by the National Natural Science Foundation of China (No. 82002172), Program for Science and Technology Development in Henan Province (Nos. 202102310205, 192102310350, and 192102310379), Key Scientific Research Project Plan of Henan Province (No. 20A180001), China Postdoctoral Science Foundation (No. 2020M682279), and Henan University Medical National Natural Science Foundation Cultivation Program."