Enhanced biocompatibility and osteogenic differentiation of mesenchymal stem cells of titanium by Sr-Ga clavate double hydroxides

作者全名："Chen, Maowen; Tao, Bailong; Hu, Yan; Li, Menghuan; Chen, Maohua; Tan, Lu; Luo, Zhong; Cai, Kaiyong"

作者地址："[Chen, Maowen; Hu, Yan; Chen, Maohua; Tan, Lu; Cai, Kaiyong] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Chongqing 400044, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Affiliated Hosp 1, Lab Res Ctr, Chongqing 400016, Peoples R China; [Li, Menghuan; Luo, Zhong] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China"

通信作者："Hu, Y; Cai, KY (corresponding author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Chongqing 400044, Peoples R China.; Luo, Z (corresponding author), Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000673173600001

JCR分区：Q2

影响因子：7

年份：2021

卷号：9

期号：30

开始页：6029

结束页：6036

文献类型：Article

关键词：　

摘要："To improve in vivo osseointegration of pure titanium implant, Sr-Ga clavate double hydroxide (CDH) coating was grown in situ on a titanium (Ti) substrate with simple hydrothermal and calcination treatments at 500 degrees C. The obtained coating on the Ti substrate (Ti-CDH and Ti-CDH500) was researched by scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive spectroscopy (EDS). Ti-CDH exhibited a sustained release profile of metal ions and maintained a slightly alkaline environment. The CDH coating was beneficial for osteogenic differentiation of mesenchymal stem cells (MSCs), which were reflected by the results of cellular assays, including alkaline phosphatase activity (ALP), cell mineralization capability (ARS), and osteogenesis-related gene expression. Besides, Ti-CDH could effectively improve the autophagic levels in MSCs, which further promoted osteogenic differentiation of MSCs. Hence, the Ti surface with Sr-Ga CDH modification supplied a simple and effective strategy to design biomaterials for bone generation."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51825302, 51773023, 21734002]; Natural Science Foundation of Chongqing Municipal GovernmentNatural Science Foundation of Chongqing [cstc2018jcyjAX0368]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2019CDQYSW005]"

基金资助正文："The work was financially supported by the National Natural Science Foundation of China (51825302, 51773023 and 21734002), Natural Science Foundation of Chongqing Municipal Government (cstc2018jcyjAX0368), and Fundamental Research Funds for the Central Universities (2019CDQYSW005)."