Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine

作者全名："Yuan, Shuai; Li, Qingshu; Chen, Kaiwen; Mu, Zhixiang; Chen, Tao; Wang, Huanan; Ji, Ping"

作者地址："[Yuan, Shuai; Chen, Tao; Ji, Ping] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China; [Li, Qingshu] Chongqing Med Univ, Dept Pathol, Chongqing 401147, Peoples R China; [Chen, Kaiwen; Wang, Huanan] Dalian Univ Technol, Sch Bioengn, Key State Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China; [Mu, Zhixiang] Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Periodont, Wenzhou 325027, Zhejiang, Peoples R China"

通信作者："Ji, P (corresponding author), Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China.; Wang, HA (corresponding author), Dalian Univ Technol, Sch Bioengn, Key State Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China."

来源：JOURNAL OF BIOLOGICAL ENGINEERING

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000675409200001

JCR分区：Q1

影响因子：5.6

年份：2021

卷号：15

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：I-PRF; Ridge preservation; Biomaterials; Gelatin; Dental implant

摘要："Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) as the potential candidate for extracted socket healing is introduced. The combination of GNPs and i-PRF not only possesses favorable mechanical properties to withstand external force but also accelerate the blood clotting time significantly. In addition, six beagle dogs were adopted to assess the angiogenic and osteogenic capacity of GNPs+i-PRF gel in vivo. The GNPs+i-PRF gel significantly produced the most blood vessels area, woven bone and low osteoclast activity in extracted sockets at 2 weeks postoperation and remarkably generated corticalization on the alveolar ridge crest at 8 weeks postoperation according to histological results. Therefore, GNPs+i-PRF gel can be recommended as the candidate grafting material regarding ridge preservation for its cost effectiveness, excellent biocompatibility, facilitation of blood clotting and favorable capacity of promoting angiogenesis and osteogenesis."

基金机构："National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701031, 31871464, 31870957]; Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2017 M622981]; Chongqing Special Postdoctoral Science Foundation [XmT2018009]; Fundamental Research Funds for the Central Universities of ChinaFundamental Research Funds for the Central Universities [DUT15RC (3)113]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81701031, 31871464 and 31870957), Postdoctoral Science Foundation of China (No. 2017 M622981), the Chongqing Special Postdoctoral Science Foundation (No. XmT2018009), and the Fundamental Research Funds for the Central Universities of China (No. DUT15RC (3)113)."