"Targeting Glioblastoma Stem Cells: A Review on Biomarkers, Signal Pathways and Targeted Therapy"

作者全名："Tang, Xuejia; Zuo, Chenghai; Fang, Pengchao; Liu, Guojing; Qiu, Yongyi; Huang, Yi; Tang, Rongrui"

作者地址："[Tang, Xuejia; Liu, Guojing; Qiu, Yongyi; Tang, Rongrui] Chongqing Med Univ, Univ Town Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Tang, Xuejia; Fang, Pengchao] Sichuan Agr Univ, Dept Pharm, Coll Vet Med, Chengdu, Peoples R China; [Zuo, Chenghai] Third Mil Med Univ, Dept Neurosurg, Army Med Univ, Chongqing, Peoples R China; [Zuo, Chenghai] Third Mil Med Univ, Key Lab Neurotrauma, Army Med Univ, Southwest Hosp, Chongqing, Peoples R China; [Huang, Yi] Ninth Peoples Hosp Chongqing, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Tang, RR (corresponding author), Chongqing Med Univ, Univ Town Hosp, Dept Neurosurg, Chongqing, Peoples R China.; Huang, Y (corresponding author), Ninth Peoples Hosp Chongqing, Dept Neurosurg, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000675583300001

JCR分区：Q2

影响因子：4.7

年份：2021

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：glioblastoma; glioblastoma stem cells; biomarkers; signal pathways; targeted therapy

摘要："Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation. Although great advances in medical development and improvements in therapeutic methods of GBM have led to a certain extension of the median survival time of patients, prognosis remains poor. The primary cause of its dismal outcomes is the high rate of tumor recurrence, which is closely related to its resistance to standard therapies. During the last decade, glioblastoma stem cells (GSCs) have been successfully isolated from GBM, and it has been demonstrated that these cells are likely to play an indispensable role in the formation, maintenance, and recurrence of GBM tumors, indicating that GSCs are a crucial target for treatment. Herein, we summarize the current knowledge regarding GSCs, their related signaling pathways, resistance mechanisms, crosstalk linking mechanisms, and microenvironment or niche. Subsequently, we present a framework of targeted therapy for GSCs based on direct strategies, including blockade of the pathways necessary to overcome resistance or prevent their function, promotion of GSC differentiation, virotherapy, and indirect strategies, including targeting the perivascular, hypoxic, and immune niches of the GSCs. In summary, targeting GSCs provides a tremendous opportunity for revolutionary approaches to improve the prognosis and therapy of GBM, despite a variety of challenges."

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