Risk factors related to postoperative recurrence of dermatofibrosarcoma protuberans: A retrospective study and literature review

作者全名："Xiong, Jian-Xia; Cai, Tao; Hu, Li; Chen, Xiao-Li; Huang, Kun; Chen, Ai-Jun; Wang, Ping"

作者地址："[Xiong, Jian-Xia; Cai, Tao; Hu, Li; Chen, Xiao-Li; Huang, Kun; Chen, Ai-Jun; Wang, Ping] Chongqing Med Univ, Affiliated Hosp Chongqing 1, Dept Dermatol, 1 Youyi Rd, Chongqing 400010, Peoples R China"

通信作者："Wang, P (corresponding author), Chongqing Med Univ, Affiliated Hosp Chongqing 1, Dept Dermatol, 1 Youyi Rd, Chongqing 400010, Peoples R China."

来源：WORLD JOURNAL OF CLINICAL CASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000676239400010

JCR分区：Q3

影响因子：1.1

年份：2021

卷号：9

期号：20

开始页：5442

结束页：5452

文献类型：Review

关键词：Dermatofibrosarcoma protuberans; Recurrence; Clinical features; Wide local excision; Surgery; Retrospective research

摘要："BACKGROUND Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade malignant soft tissue tumor characterized by rosette-like infiltrative growth. Postoperative recurrence of this tumor is very common. AIM To evaluate the risk factors related to recurrence after wide local excision (WLE) of DFSP and to guide clinical diagnosis and treatment. METHODS The medical records of 44 DFSP patients confirmed by pathology at our hospital from 2012 to 2019 were retrospectively reviewed. The relationship between clinical features, tumor characteristics, treatment, and recurrence risk were analyzed, and the possible risk factors for postoperative tumor recurrence were evaluated. RESULTS There were 44 patients in total, including 21 males and 23 females. The median progression free survival was 36 mo (range, 1-240 mo). Twenty patients were treated for the first time, while 24 had previous treatment experience. Forty-two cases were followed for 25.76 22.0 mo, among whom four (9.52%) experienced recurrence after WLE (rate was 9.52%). The recurrence rate in the recurrent group was higher than that in the patients with primary tumor (19.05% vs 0%, P = 0.028). Eighteen cases had a history of misdiagnosis (rate was 40.91%). The recurrence rate among patients with previous experience of misdiagnosis was significantly higher than in patients without (68% vs 36.84%, P = 0.04). The tumor diameter in patients with a history of treatment was larger than in patients treated for the first time (4.75 +/- 0.70 cm vs 2.25 +/- 0.36 cm, P = 0.004). CONCLUSION To sum up, the clinical manifestations of DFSP are not specific and are easily misdiagnosed, thus commonly causing the recurrence of DFSP. After incomplete resection, the tumor may rapidly grow. Previous recurrence history may be a risk factor for postoperative recurrence, and tumor location may have an indirect effect on postoperative recurrence; however, we found no significant correlation between sex, age, course of the disease, or tumor size and postoperative recurrence."

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