The impact of selenium administration on severe sepsis or septic shock: a meta-analysis of randomized controlled trials

作者全名："Kong, Lin; Wu, Qing; Liu, Bo"

作者地址："[Kong, Lin] Chongqing Med Univ, Dept Clin Nutr, Childrens Hosp, Chongqing 400014, Peoples R China; [Wu, Qing] Chongqing Med Univ, Dept Pharm, Childrens Hosp, Chongqing 400014, Peoples R China; [Liu, Bo] Chongqing Med Univ, Dept Gastroenterol, Childrens Hosp, Chongqing 400014, Peoples R China; [Kong, Lin; Wu, Qing; Liu, Bo] Chongqing Med Univ, Minist Educ Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders,Children, Chongqing Key Lab Pediat,China Int Sci & Technol, Chongqing 400014, Peoples R China"

通信作者："Liu, B (corresponding author), Chongqing Med Univ, Dept Gastroenterol, Childrens Hosp, Chongqing 400014, Peoples R China."

来源：AFRICAN HEALTH SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000677673800034

JCR分区：Q2

影响因子：1

年份：2021

卷号：21

期号：1

开始页：277

结束页：285

文献类型：Article

关键词：Selenium administration; septic shock; randomized controlled trials

摘要："Introduction: The efficacy of selenium administration to treat severe sepsis or septic shock remains controversial. We con- duct a systematic review and meta-analysis to explore the impact of selenium administration on severe sepsis or septic shock. Methods: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020 for randomized controlled trials (RCTs) assessing the effect of selenium administration on severe sepsis or septic shock. Me- ta-analysis is performed using the random-effect model. Results: Five RCTs involving 1482 patients are included in the meta-analysis. Overall, compared with control group in septic patients, selenium administration is not associated with reduced 28-day mortality (RR=0.93; 95% CI=0.73 to 1.19; P=0.58), but results in substantially decreased all-cause mortality (RR=0.78; 95% CI=0.63 to 0.98; P=0.03) and length of hospital stay (MD=-3.09; 95% CI=-5.68 to-0.50; P=0.02). Conclusion: Selenium administration results in notable decrease in all-cause mortality and length of hospital stay, but shows no substantial influence on the 28-day mortality, length of ICU stay, duration of vasopressor therapy, the incidence of acute renal failure, adverse events, and serious adverse events for septic patients."

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