Clinical significance and prognostic role of an immune-related gene signature in gastric adenocarcinoma

作者全名："Mao, Rui; Liu, Kehao; Zhao, Nana; Guo, Pengsen; Wu, Yingxin; Wang, Zheng; Liu, Yanjun; Zhang, Tongtong"

作者地址："[Mao, Rui; Liu, Kehao; Guo, Pengsen; Wu, Yingxin; Liu, Yanjun; Zhang, Tongtong] Southwest Jiaotong Univ, Affiliated Hosp, Peoples Hosp Chengdu 3, Ctr Gastrointestinal & Minimally Invas Surg,Dept, Chengdu 610031, Peoples R China; Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China; [Zhao, Nana] Third Peoples Hosp Chengdu, Dept Operating Room, Chengdu 610031, Peoples R China; [Mao, Rui; Liu, Yanjun; Zhang, Tongtong] Southwest Jiaotong Univ, Affiliated Hosp, Chengdu 610036, Peoples R China; [Wang, Zheng] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Colorectal Surg,Natl Canc Ctr, Beijing 100021, Peoples R China; [Zhang, Tongtong] Chongqing Med Univ, Chengdu Hosp Affiliated 2, Affiliated Hosp Southwest Jiaotong Univ, Med Res Ctr,Peoples Hosp Chengdu 3, Chengdu 610031, Peoples R China"

通信作者："Liu, YJ; Zhang, TT (corresponding author), Southwest Jiaotong Univ, Affiliated Hosp, Peoples Hosp Chengdu 3, Ctr Gastrointestinal & Minimally Invas Surg,Dept, Chengdu 610031, Peoples R China.; Zhang, TT (corresponding author), Southwest Jiaotong Univ, Affiliated Hosp, Chengdu 610036, Peoples R China.; Wang, Z (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Colorectal Surg,Natl Canc Ctr, Beijing 100021, Peoples R China.; Zhang, TT (corresponding author), Chongqing Med Univ, Chengdu Hosp Affiliated 2, Affiliated Hosp Southwest Jiaotong Univ, Med Res Ctr,Peoples Hosp Chengdu 3, Chengdu 610031, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000678036300001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：13

期号：13

开始页：17734

结束页：17767

文献类型：Article

关键词：gastric adenocarcinoma; qRT-PCR; prognosis; immune signature; tumor microenvironment

摘要："Limited progress has been made in the treatment of gastric adenocarcinoma (GAC) in recent years, but the potential of immunotherapy in GAC is worthy of consideration. The purpose of this study was to develop a reliable, personalized signature based on immune genes to predict the prognosis of GAC. Here, we identified two groups of patients with significantly different prognoses by performing unsupervised clustering analysis of The Cancer Genome Atlas (TCGA) database based on 881 immune genes. The immune signature was constructed with a training set composed of 350 GAC samples from the TCGA and subsequently validated with 431 samples from GSE84437, 432 samples from GSE26253, and 145 GAC samples from real-time quantitative reverse transcription polymerase chain reaction data. This classification system can also be used to predict prognosis in different clinical subgroups. Further analysis suggested that high-risk patients were characterized by low immune scores, distinctive immune cell proportions, different immune checkpoint profiles, and a low tumor mutational burden. Ultimately, the signature was identified as an independent prognostic factor. In general, the signature can accurately predict recurrence and overall survival in patients with GAC and may serve as a powerful prognostic tool to further optimize cancer immunotherapy."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502075]; Foundation of Science and Technology of Sichuan Province [2019YJ0635]

基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (81502075) and the Foundation of Science and Technology of Sichuan Province (2019YJ0635). The funders had no role in the study design or implementation.