Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

作者全名："Zeng, Wu; Wu, An Guo; Zhou, Xiao-Gang; Khan, Imran; Zhang, Rui Long; Lo, Hang Hong; Qu, Li Qun; Song, Lin Lin; Yun, Xiao Yun; Wang, Hui Miao; Chen, Juan; Ng, Jerome P. L.; Ren, Fang; Yuan, Si Yu; Yu, Lu; Tang, Yong; Huang, Guo Xin; Wong, Vincent Kam Wai; Chung, Sookja Kim; Mok, Simon Wing Fai; Qin, Da Lian; Sun, Hua Lin; Liu, Liang; Hsiao, W. L. Wendy; Law, Betty Yuen Kwan"

作者地址："[Zeng, Wu; Khan, Imran; Zhang, Rui Long; Lo, Hang Hong; Qu, Li Qun; Song, Lin Lin; Yun, Xiao Yun; Wang, Hui Miao; Ng, Jerome P. L.; Tang, Yong; Huang, Guo Xin; Wong, Vincent Kam Wai; Sun, Hua Lin; Liu, Liang; Hsiao, W. L. Wendy; Law, Betty Yuen Kwan] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China; [Wu, An Guo; Zhou, Xiao-Gang; Yu, Lu; Tang, Yong; Qin, Da Lian] Southwest Med Univ, Sch Pharm, Sichuan Key Med Lab New Drug Discovery & Drug Abi, Key Lab Med Electrophysiol,Minist Educ, Luzhou, Peoples R China; [Chen, Juan; Ren, Fang; Yuan, Si Yu] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Chinese Minist Educ,Key Lab Mol B, Chongqing, Peoples R China; [Chung, Sookja Kim; Mok, Simon Wing Fai] Macau Univ Sci & Technol, Dept Med, Taipa, Macau, Peoples R China; [Zeng, Wu] Bioland Lab, Dept Ctr Neurometab & Regenerat Res, Guangzhou, Peoples R China"

通信作者："Liu, L; Hsiao, WLW; Law, BYK (corresponding author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China."

来源：PHARMACOLOGICAL RESEARCH

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000680035100022

JCR分区：Q1

影响因子：9.3

年份：2021

卷号：170

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Complement system; Aging; Gut microbiota; C. elegans; Neurodegenerative disease

摘要："With the increase in human lifespan, population aging is one of the major problems worldwide. Aging is an irreversible progressive process that affects humans via multiple factors including genetic, immunity, cellular oxidation and inflammation. Progressive neuroinflammation contributes to aging, cognitive malfunction, and neurodegenerative diseases. However, precise mechanisms or drugs targeting age-related neuroinflammation and cognitive impairment remain un-elucidated. Traditional herbal plants have been prescribed in many Asian countries for anti-aging and the modulation of aging-related symptoms. In general, herbal plants' efficacy is attributed to their safety and polypharmacological potency via the systemic manipulation of the body system. Radix polygalae (RP) is a herbal plant prescribed for anti-aging and the relief of age-related symptoms; however, its active components and biological functions remained un-elucidated. In this study, an active methanol fraction of RP containing 17 RP saponins (RPS), was identified. RPS attenuates the elevated C3 complement protein in aged mice to a level comparable to the young control mice. The active RPS also restates the aging gut microbiota by enhancing beneficial bacteria and suppressing harmful bacteria. In addition, RPS treatment improve spatial reference memory in aged mice, with the attenuation of multiple molecular markers related to neuroinflammation and aging. Finally, the RPS improves the behavior and extends the lifespan of C. elegans, confirming the herbal plant's anti-aging ability. In conclusion, through the mouse and C. elegas models, we have identified the beneficial RPS that can modulate the aging process, gut microbiota diversity and rectify several aging-related phenotypes."

基金机构："Macao Science and Technology Development Fund, Macau, China [0060/2018/A2, 0036/2018/AFJ]; Foshan Medicine Dengfeng Project, China (2019-2021); National Natural Science Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81903829]; Science and Technology Planning Project of Sichuan Province, China [2018JY0474]"

基金资助正文："This work was supported by grants from the Macao Science and Technology Development Fund, Macau, China (Project Code: 0060/2018/A2 and 0036/2018/AFJ), Foshan Medicine Dengfeng Project, China (2019-2021), the National Natural Science Foundation of China, China (Grant No. 81903829), and the Science and Technology Planning Project of Sichuan Province, China (Grant no. 2018JY0474)."