Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial

作者全名："Zhong, Guo-Chao; Hu, Tian-Yang; Yang, Peng-Fei; Peng, Yang; Wu, Jing-Jing; Sun, Wei-Ping; Cheng, Long; Wang, Chun-Rui"

作者地址："[Zhong, Guo-Chao] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Hu, Tian-Yang] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Yang, Peng-Fei] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, Chongqing, Peoples R China; [Peng, Yang] Fifth Peoples Hosp Chengdu, Dept Geriatr, Chengdu, Peoples R China; [Wu, Jing-Jing] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Sun, Wei-Ping] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Cheng, Long] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Chun-Rui] Chongqing Med Univ, Dept Infect Dis, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Chinese Minist Educ,A, Chongqing, Peoples R China"

通信作者："Cheng, L (corresponding author), Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China.; Wang, CR (corresponding author), Chongqing Med Univ, Dept Infect Dis, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Chinese Minist Educ,A, Chongqing, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000680282000001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：13

期号：14

开始页：18564

结束页：18585

文献类型：Article

关键词：chocolate; mortality; cardiovascular disease; cancer

摘要："Few studies with mixed results have examined the association between chocolate consumption and mortality. We aimed to examine this association in a US population. A population-based cohort of 91891 participants aged 55 to 74 years was identified. Chocolate consumption was assessed via a food frequency questionnaire. Cox regression was used to estimate risk estimates. After an average follow-up of 13.5 years, 19586 all-cause deaths were documented. Compared with no regular chocolate consumption, the maximally adjusted hazard ratios of all-cause mortality were 0.89 [95% confidence interval (CI) 0.84-0.94], 0.84 (95% CI 0.79-0.90), 0.86 (95% CI 0.81-0.93), and 0.87 (95% CI 0.82-0.93) for 0-0.5 servings/week, >0.5-1 serving/week, >1-2 servings/week, and >2 servings/week, respectively (P-trend = 0.009). A somewhat stronger inverse association was observed for mortality from cardiovascular disease and Alzheimer's disease. A nonlinear dose-response pattern was found for all-cause and cardiovascular mortality (all P-nonlinearity < 0.01), with the lowest risk observed at chocolate consumption of 0.7 servings/week and 0.6 servings/week, respectively. The favorable associations with all-cause and cardiovascular mortality were found to be more pronounced in never smokers than in current or former smokers (all Pinteraction < 0.05). In conclusion, chocolate consumption confers reduced risks of mortality from all causes, cardiovascular disease, and Alzheimer's disease in this US population."

基金机构：　

基金资助正文：