A Novel Nomogram Based on Hepatic and Coagulation Function for Evaluating Outcomes of Intrahepatic Cholangiocarcinoma After Curative Hepatectomy: A Multi-Center Study of 653 Patients
作者全名："Cai, Yunshi; Zhang, Bohan; Li, Jiaxin; Li, Hui; Liu, Hailing; Xie, Kunlin; Du, Chengyou; Wu, Hong"
作者地址："[Cai, Yunshi; Zhang, Bohan; Li, Jiaxin; Li, Hui; Liu, Hailing; Xie, Kunlin; Wu, Hong] Sichuan Univ, West China Hosp, Dept Liver Surg & Liver Transplantat, State Key Lab Biotherapy, Chengdu, Peoples R China; [Cai, Yunshi; Zhang, Bohan; Li, Jiaxin; Li, Hui; Liu, Hailing; Xie, Kunlin; Wu, Hong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China; [Cai, Yunshi; Zhang, Bohan; Li, Jiaxin; Li, Hui; Liu, Hailing; Xie, Kunlin; Wu, Hong] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China; [Du, Chengyou] Chongqing Med Univ, Dept Hepatobiliary Surg & Liver Transplantat, Affiliated Hosp 1, Chongqing, Peoples R China"
通信作者："Wu, H (corresponding author), Sichuan Univ, West China Hosp, Dept Liver Surg & Liver Transplantat, State Key Lab Biotherapy, Chengdu, Peoples R China.; Wu, H (corresponding author), Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.; Wu, H (corresponding author), Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China.; Du, CY (corresponding author), Chongqing Med Univ, Dept Hepatobiliary Surg & Liver Transplantat, Affiliated Hosp 1, Chongqing, Peoples R China."
来源：FRONTIERS IN ONCOLOGY
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000680576200001
JCR分区：Q2
影响因子：4.7
年份：2021
卷号：11
期号：
开始页：
结束页：
文献类型：Article
关键词：gamma-glutamyl transpeptidase; GGT to platelet ratio; intrahepatic cholangiocarcinoma; international normalized ratio; nomogram
摘要："Background and Aims: Hepatic and coagulation function are routine laboratory tests prior to curative hepatectomy. The prognostic value of gamma-glutamyl transpeptidase (GGT) to platelet ratio (GPR) and international normalized ratio (INR) in surgically treated patients with intrahepatic cholangiocarcinoma (ICC) remains unclear. Methods: ICC patients received curative hepatectomy in two west China centers were included. Time-dependent ROC curves were conducted to compare established indexes with prognostic value for ICC. GPR-INR score was introduced and evaluated using the Time-dependent AUC curve and Kaplan-Meier survival analysis. A novel nomogram based on the GPR-INR score was proposed; Harrell's C-index, calibration curve and decision curve analysis were used to assess this nomogram. Results: A total of 653 patients were included. The areas under ROC curves of GPR and INR in OS and RFS were superior to other indexes. Patients with a high GPR-INR score (1,2) presented significantly decreased overall survival (OS) and recurrence-free survival (RFS); GPR-INR sore, along with several clinicopathological indexes were selected into the nomogram, the calibration curve for OS probability showed good coincidence between the nomogram and the actual surveillance. The C-index of the nomogram was 0.708 (derivation set) and 0.746 (validation set), which was more representative than the C-indexes of the GPR-INR score (0.597, 0.678). In decision curve analysis, the net benefits of the nomogram in derivation and validation set were higher than Barcelona Clinic Liver Cancer staging (BCLC) classification and American Joint Committee on Cancer (AJCC) TNM 8(th) staging system. Conclusions: The proposed nomogram generated superior discriminative ability to established staging systems; it is profitable to applicate this nomogram in clinical practice."
基金机构："National Key Technologies RD ProgramNational Key Technology R&D Program [2018YFC1106800]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972747, 81872004, 81800564, 81770615, 81700555, 81672882]; Science and Technology Support Program of Sichuan Province [2019YFQ0001, 2018SZ0115, 2017SZ0003]; Science and Technology Program of Tibet Autonomous Region [XZ201801-GB-02]; 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC18008]; 2021 Sichuan Science andTechnology Plan Project ""International cooperation in science and technology innovation/technological innovation cooperation in Hong Kong, Macao and Taiwan""; Artificial intelligence assisted precise diagnosis and minimally invasive treatment of liver tumor diseases [2021YFH0095]"
基金资助正文："This work was supported by grants from the National Key Technologies R&D Program (2018YFC1106800), the Natural Science Foundation of China (81972747, 81872004, 81800564, 81770615, 81700555 and 81672882), the Science and Technology Support Program of Sichuan Province ( 2019YFQ0001, 2018SZ0115, 2017SZ0003), the Science and Technology Program of Tibet Autonomous Region (XZ201801-GB-02) and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18008), 2021 Sichuan Science and Technology Plan Project ""International cooperation in science and technology innovation/technological innovation cooperation in Hong Kong, Macao and Taiwan"", Artificial intelligence assisted precise diagnosis and minimally invasive treatment of liver tumor diseases (2021YFH0095)."
