The Association Between Resting State Functional Connectivity and the Trait of Impulsivity and Suicidal Ideation in Young Depressed Patients With Suicide Attempts

作者全名："Cao, Jun; Chen, Xiaorong; Chen, Jianmei; Ai, Ming; Gan, Yao; He, Jinglan; Kuang, Li"

作者地址："[Cao, Jun; Chen, Jianmei; Ai, Ming; Gan, Yao; He, Jinglan; Kuang, Li] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Xiaorong] Chongqing Med Univ, Mental Hlth Ctr, Univ Town Hosp, Chongqing, Peoples R China"

通信作者："Kuang, L (corresponding author), Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China.; Chen, XR (corresponding author), Chongqing Med Univ, Mental Hlth Ctr, Univ Town Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000683566700001

JCR分区：Q2

影响因子：4.7

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：youth suicide; depression; functional magnetic resonance imaging; impulsivity; resting-state functional connectivity

摘要："Suicide is a leading cause of death among youth and is strongly associated with major depressive disorder (MDD). However, the neurobiological underpinnings of suicidal behaviour and the identification of risk for suicide in young depressed patients are not yet well-understood. In this study, we used a seed-based correlation analysis to investigate the differences in resting-state functional connectivity (RSFC) in depressed youth with or without a history of suicide attempts and healthy controls (HCs). Suicidal attempters (ATT group, n = 35), non-suicide attempters (NAT group, n = 18), and HCs exhibited significantly different RSFC patterns with the left superior prefrontal gyrus (L-SFG) and left middle prefrontal gyrus (L-MFG) serving as the regions of interest (ROIs). The ATT group showed decreased RSFC of the left middle frontal gyrus with the left superior parietal gyrus compared to the NAT and HC groups. Decreased RSFC between the left superior frontal gyrus and the right anterior cingulate cortex (rACC) was found in the ATT group compared to the NAT and HC groups. Furthermore, the left prefrontal-parietal connectivity was associated with suicidal ideation and levels of impulsivity, but RSFC of the left prefrontal cortex with the rACC was correlated exclusively with impulsivity levels and was not related to suicidal ideation in the ATT group. Our results demonstrated that altered RSFC of the prefrontal-parietal and prefrontal-rACC regions was associated with suicide attempts in depressed youth, and state-related deficits in their interconnectivity may contribute to traits, such as cognitive impairments and impulsivity to facilitate suicidal acts. Our findings suggest that the neural correlates of suicidal behaviours might be dissociable from those related to the severity of current suicidal ideation. Neural circuits underlying suicide attempts differ from those that underlie suicidal ideation."

基金机构：Medicine Scientific Research Fund for Youth from Chongqing Health and Family Planning Committee [2018QNXM014]; Natural Science Fund from Chongqing Science and Technology Commission [cstc2018jcyjAX0164]; Scientific Research and Cultivation Project of the First Affiliated Hospital of Chongqing Medical University [PYJJ2018-20]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671360]

基金资助正文："This research was supported by the Medicine Scientific Research Fund for Youth from Chongqing Health and Family Planning Committee (2018QNXM014), the Natural Science Fund from Chongqing Science and Technology Commission (cstc2018jcyjAX0164), the Scientific Research and Cultivation Project of the First Affiliated Hospital of Chongqing Medical University (PYJJ2018-20), and the National Natural Science Foundation of China (81671360)."