Reversal of Enantioselectivity in the Copper-Aminophenol Sulfonamide Catalyzed Alkynylation of Isatins by Slightly Tuning the Ligand Structure and Basic Additives

作者全名："He, Huakang; Yang, Zinan; Chai, Yu; Wu, Ruoran; Chen, Peng; Zhou, Jing; Zhou, Hui"

作者地址："[He, Huakang; Yang, Zinan; Chai, Yu; Wu, Ruoran; Chen, Peng; Zhou, Jing; Zhou, Hui] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Zhou, J; Zhou, H (corresponding author), Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：ORGANIC LETTERS

ESI学科分类：CHEMISTRY

WOS号：WOS:000684033200106

JCR分区：Q1

影响因子：5.2

年份：2021

卷号：23

期号：15

开始页：5739

结束页：5743

文献类型：Article

关键词：　

摘要：A series of new chiral aminophenol sulfonamide ligands with a monochiral arm has been developed for the first Cu(I) catalyzed enantiodivergent alkynylation of isatins. Dramatic reversal of enantioselectivity was accomplished by slightly tuning the substituted benzenesulfonamide and achiral basic additives. A wide range of both terminal alkynes and isatins are tolerated by this new catalyst system with up to 99% yield and 97% ee.

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672031]; Natural Science Foundation of ChongqingNatural Science Foundation of Chongqing [cstc2019jcyj-msxmX0034]; Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN201900437]

基金资助正文："The work is supported by the National Natural Science Foundation of China (21672031), Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0034), and Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJQN201900437)."