Increased occurrence of PTSD symptoms in adolescents with major depressive disorder soon after the start of the COVID-19 outbreak in China: a cross-sectional survey

作者全名："Zhang, Hang; Xu, Hanmei; Huang, Lijuan; Wang, Yanping; Deng, Fang; Wang, Xiaolan; Tang, Xiaowei; Wang, Wo; Fu, Xia; Tao, Yuanmei; Yin, Li"

作者地址："[Zhang, Hang; Xu, Hanmei; Huang, Lijuan; Wang, Yanping; Wang, Xiaolan; Tang, Xiaowei; Fu, Xia; Tao, Yuanmei; Yin, Li] Sichuan Univ, West China Hosp, Mental Hlth Ctr, 28 Dianxin South St, Chengdu 610041, Sichuan, Peoples R China; [Deng, Fang] Fourth Peoples Hosp Chengdu, Chengdu 610036, Sichuan, Peoples R China; [Wang, Wo] Chongqing Med Univ, Univ Town Hosp, 55 Univ Town Middle Rd, Chongqing 400000, Peoples R China; [Yin, Li] Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu 610041, Sichuan, Peoples R China"

通信作者："Yin, L (corresponding author), Sichuan Univ, West China Hosp, Mental Hlth Ctr, 28 Dianxin South St, Chengdu 610041, Sichuan, Peoples R China.; Yin, L (corresponding author), Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu 610041, Sichuan, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000685078400002

JCR分区：Q2

影响因子：4.4

年份：2021

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19; PTSD; MDD; Adolescents; CRIES-13

摘要："Background: The Coronavirus Disease 2019 (COVID-19) pandemic continues to threaten the physical and mental health of people across the world. This study aimed to understand the psychological impact of this disease on adolescents with major depressive disorder (MDD) at 1 month after the start of the outbreak in China. Methods: Using the Children's Impact of Event Scale (CRIES-13) questionnaire, we investigated the occurrence of posttraumatic stress disorder (PTSD) in two groups of adolescents: MDD patients who were in continuous antidepressant therapy and healthy controls. Total scores and factor subscores were compared between the two groups and subgroups stratified by sex and school grade. Logistic regression was used to identify variables associated with high total CRIES-13 scores. Results: Compared to controls (n = 107), the MDD group (n = 90) had higher total CRIES-13 scores and a higher proportion with a total score >= 30. They also had a lower intrusion subscore and a higher arousal subscore. In the MDD group, males and females did not differ significantly in total CRIES-13 scores or factor subscores, but junior high school students had higher avoidance subscores than senior high school students. Logistic regression showed high total CRIES-13 scores to be associated with MDD and the experience of ""flashbacks"" or avoidance of traumatic memories associated with COVID-19. Conclusions: It is crucial to understand the psychological impact of COVID-19 on adolescents with MDD in China, especially females and junior high school students. Long-term monitoring of adolescents with a history of mental illness is required to further understand these impacts."

基金机构："National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81801357]; Science and Technology Education Program of the Sichuan Province [2020JDKP0013, 2020YFS0259]; Chengdu Key Technology RD Program [2019-YF05-00284-SN]"

基金资助正文："This work was supported by the National Nature Science Foundation of China (81801357), the Science and Technology Education Program of the Sichuan Province (2020JDKP0013, 2020YFS0259), and the Chengdu Key Technology R&D Program (2019-YF05-00284-SN). The above mentioned funding bodies had no further role in the study design, collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication."